Whitehead Institute for Biomedical Research

Yaqub Hanna

Rudolf Jaenisch

Alexander Meissner

Ruth Foreman

G Grant Welstead

Marius Wernig

Christopher J Lengner

Oliver Tobias Brambrink

Bryce Woodbury Carey

The disclosure relates to a method of reprogramming one or more somatic cells, e.g., partially differentiated or fully/terminally differentiated somatic cells, to a less differentiated state, e.g., a pluripotent or multipotent state. In further embodiments the invention also relates to reprogrammed somatic cells produced by methods of the invention, to chimeric animals comprising reprogrammed somatic cells of the invention, to uses of said cells, and to methods for identifying agents useful for reprogramming somatic cells.

Nucleic acid constructs encoding reprogramming factors linked by self-cleaving peptides

The disclosure relates to a method of reprogramming one or more somatic cells, e.g., partially differentiated or fully/terminally differentiated somatic cells, to a less differentiated state, e.g., a pluripotent or multipotent state. In further embodiments the invention also relates to reprogrammed somatic cells produced by methods of the invention, to uses of said cells, and to methods for identifying agents useful for reprogramming somatic cells.

Reprogramming of somatic cells

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Boston, MA, United States of America

Yaqub Hanna