Chinese Academy of Sciences

Institute of Pharmacology and Toxicology Academy of Military Medical Sciences Pla China

Zhejiang Xianju Pharmaceuticals Co. Ltd.

Yaping Wang

Rixiang Zhu

Wenyang Wang

Xiongqi Pang

Zhangxing Chen

Tao Hu

Wang Zhang

Wei Hu

Bohua Zhong

Zuoyan Zhu

Zehui Gong

Shuangfei Li

Yongshao Liu

A method, system and device for comprehensively characterizing a lower limit of oil accumulation of a deep marine carbonate reservoir is provided, aiming to solve the problem that the prior art cannot: accurately determine the lower limit of oil accumulation of the deep marine carbonate reservoir, which leads to the difficulty in predicting and identifying deep effective reservoirs. The method includes: determining lower limit porosity and permeability for oil accumulation based on a boundary line; determining lower limit porosity and permeability for oil accumulation based on a movable oil ratio of a core sample; determining a lower limit pore throat radius for oil accumulation based on a mercury injection experiment; and comprehensively characterizing the lower limit of oil accumulation of a deep marine carbonate reservoir to be predicted. The method, system and device can predict and identify deep effective reservoirs.

Method for comprehensively characterizing lower limit of oil accumulation of deep marine carbonate reservoir

An evaluation method for residual hydrocarbon of post- to over-mature marine source rocks includes the following steps: establishing a hydrocarbon generation potential evolution profile and a hydrogen index evolution profile of post- to over-mature source rocks; determining a critical condition for hydrocarbon expulsion of the source rocks, and inverting original hydrocarbon generation potential of the source rocks; inverting a critical condition for hydrocarbon generation of the source rocks; establishing a hydrocarbon generation, expulsion and retention model for the source rocks; determining a hydrocarbon generation rate, a hydrocarbon expulsion rate and a hydrocarbon retention rate of the source rocks; and calculating a hydrocarbon retention intensity and residual hydrocarbon of the source rocks. The evaluation method establishes an evaluation model for residual hydrocarbon of post- to over-mature source rocks without relying on immature to sub-mature samples.

Evaluation method for residual hydrocarbon of post- to over-mature marine source rocks

A method, system and device for predicting an oil accumulation depth limit of deep and ultra-deep marine carbonate reservoirs is provided. The method includes: obtaining geological factors acting on a porosity of a deep/ultra-deep marine carbonate reservoir, standardizing absolute values of the geological factors; calculating a porosity of the deep/ultra-deep marine carbonate reservoir; acquiring ratios of oil, water and dry layers in each M % porosity interval, and acquiring a relationship between a dry layer ratio and the porosity of the deep/ultra-deep marine carbonate reservoir; recursively obtaining a relationship between the dry layer ratio and the burial depth and determining the oil accumulation depth limit of the deep/ultra-deep marine carbonate reservoir. The method, system and device solves the problem that the prior art cannot by predicting the oil accumulation depth limit directly through the relationship between the dry layer ratio and the depth.

Method for predicting oil accumulation depth limit of deep and ultra-deep marine carbonate reservoirs

The present application disclosed a method for preparing a sterile transgenic fish, comprising constructing antisense RNA expression vector of salmon-type gonadotropin-releasing hormone, introducing the recombinant DNA fragment into carp oosperm by microinjection, and screening the sterile transgenic fish by Polymerase Chain Reaction and radioimmunoassay, wherein the expression vector comprising a promoter of carp beta actin (&#x3b2;-actin) gene, a complementary DNA fragment of antisense salmon-type gonadotropin-releasing hormone (sGnRH) gene from carp with 323 bp as a target gene comprising sGnRH decapeptide, the coding region of gonadotropin-releasing hormone associated peptide and 3' non-coding sequence, and 3&#x2032; flanking sequence of grass carp growth hormone gene as a stop sequence. The method of the present invention is easy and convenient for operation which provides a basis for providing a technical platform of general applicability for solving the hereditary and ecological safety problems of transgenic fishes.

Method for preparing a sterile transgenic carp

The present invention relates to oripavine derivatives of formula (I), 

Oripavine derivatives and their uses as pharmaceuticals

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Beijing, China

Yaping Wang