Biogen Idec Ma Inc.

Yaping Sun

Yen-Ming Hsu

Christine Ambrose

Jeffrey Thompson

Dingyi Wen

The disclosure provides a non-naturally occurring BAFF-R glycoprotein having a deletion in the extracellular domain which results in an altered O-linked glycosylation pattern. The disclosure also provides methods and pharmaceutical compositions for treating B-cell- and T-cell-mediated disorders.

Method of treating B cell cancers by administering truncated BAFF receptors

The disclosure provides a non-naturally occurring BAFF-R glycoprotein having a deletion in the extracellular domain which results in an altered 0-linked glycosylation pattern. The disclosure also provides methods and pharmaceutical compositions for treating B-cell- and T-cell-mediated disorders.

Method of treating immunological disorders by administering truncated BAFF receptors

Truncated BAFF receptors

Truncated baff receptors

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Lexington, MA, United States of America

Yaping Sun