Nanjing Tech University

Yaping Fu

Ming Li

Yong Chen

Dong Liu

Hanjie Ying

Wei Zhuang

Chenjie Zhu

Huanqing Niu

Zhuotao Tan

Pengpeng Yang

Yaoying Han

A method for preparing a nitrogen-containing heterocyclic compound and a derivative thereof by an enzymatic-chemical cascade method, comprising: reacting an alcohol, an amine, an alcohol dehydrogenase, a flavin molecule and a coenzyme in a solvent to obtain the nitrogen-containing heterocyclic compound and the derivative thereof; compared with the prior art, the method is a green and economical enzymatic-chemical cascade method, and is used for synthesizing nitrogen-containing heterocyclic compounds and derivatives thereof; compared with a common toxic chemical catalyst, the alcohol dehydrogenase is selected as a catalyst in the method, which has the characteristics of high substrate specificity, no pollution, high catalytic efficiency, no toxic solvents and simple post-treatment.

Method for preparing nitrogen-containing heterocyclic compound and derivative thereof by enzymatic-chemical cascade method

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Nanjing, China

Yaping Fu