Merck Sharp + Dohme Corp.

Yaozong Li

Yongxin Han

Yunfu Luo

Christopher S Burgey

Kenneth L Arrington

Jiayi Xu

Mehul F Patel

Robert Gilfillan

Chun Sing Li

Christopher Burgey

Mehul Patel

Compounds of Formula I: are HIV reverse transcriptase inhibitors, wherein R, R, R, L, M and Z are defined herein. The compounds of Formula I and their pharmaceutically acceptable salts are useful in the inhibition of HIV reverse transcriptase, the prophylaxis and treatment of infection by HIV and in the prophylaxis, delay in the onset or progression, and treatment of AIDS. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.

Non-nucleoside reverse transcriptase inhibitors

Growing community of inventors

Shanghai, China

Yaozong Li