Kosan Biosciences Incorporated

Evolva Sa

Pfizer Corporation

Emergent Product Development Gaithersburg Inc.

Yaoquan Liu

David C Myles

Jorgen Hansen

Jens Houghton-Larsen

Zong-Qiang Tian

Nina Nicoline Rasmussen

Zhan Wang

Sathish Kumar

Muthuswamy Panchapagesa Murali

Christopher Carreras

Daniel V Santi

Peter Schneider

Hong Fu

Jutta Heim

Patrick Roussel

Christian Bartels

Angelika Semmler

Daniel Milligan

Katarzyna Krzystanek

Monika Khare

Jung Yeop Lee

Soren Damkiaer

Iver Klavs Riishede Hansen

Brian Walter Metcalf

Robert G McDaniel

Yandong Li

Glenn E Dale

Yue Chen

Mark A Burlingame

Simon James Shaw

Yong Li

Glen Dale

Eduardo J Rodriguez

Hao Zheng

Gary Liu

Methods for recombinant and enzymatic production of mogroside compounds and compositions containing mogroside compounds are provided by this invention.

Methods and materials for biosynthesis of mogroside compounds

Methods and materials for enzymatic synthesis of mogroside compounds described.

Methods and materials for enzymatic synthesis of mogroside compounds

The invention relates to methods for producing mogrosides with the aid of enzymes. In particular the invention proposes various biosynthetic pathways useful for mogroside production and enzymes useful for mogroside production are provided. Furthermore, the invention provides recombinant hosts useful in performing the methods of the invention.

Disclosed herein are compounds of Formula I 

2-pyridone antimicrobial compositions

Described are a series of 2-pyridone compounds as a potent and selective new class of type II topoisomerase inhibitors with broad-spectrum antimicrobial activity having the general formula (I); where R1, R2, X, and Y are defined herein Such compounds can be used in methods for treating an infection caused by a gram-positive pathogen, a gram-negative pathogen, or a drug-resistant strains thereof. 

Carbamate compounds having a structure represented by formula I (where R, R, R, R, Rand Rare as defined herein) are useful as anti-tumor agents. 

Carbamate compounds

Compounds having a structure according to formula (I) where R, R, R, R, R, and Rare as defined herein, are useful as prokinetic agents.

Motilide compounds

Compounds having the structure of formula I wherein R, R, R, R, R, and Rare as defined herein, are prokinetic agents and can be used to treat disorders of gastric motility.

N-desmethyl-N-substituted-11-deoxyerythromycin compounds

Geldanamycin compounds having a structure according to formula I where Q, L, L, R, R, and Rare as defined herein, are useful for treating a disease or disorder ameliorated by inhibiting the function of extracellular heat shock protein-90.

Geldanamycin compounds and method of use

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Castro Valley, CA, United States of America

Yaoquan Liu