Suzhou Sinovent Pharmaceuticals Co., Ltd.

Hangzhou Rex Pharmaceutical Co., Ltd.

Hangzhou Yuanchang Medical Sci-tech Co., Ltd

Hangzhou Minsheng Institutes for Pharma Research Co., Ltd

Yaodong Wu

Dong Wang

Ximing Shen

Yujun Gao

Yonghui Wang

Juan Zhou

Binbin Hong

Chunqi Li

Tao Liu

Binnan Huang

Yan Zhu

Shiqun Wang

Wandeng Liu

Jiaqi Shan

Chunxia Wu

A five-membered heterocyclic amide WNT pathway inhibitor having the following general structural formula: The five-membered heterocyclic amide WNT pathway inhibitor has a remarkable anti-tumor activity based on a target-based rational drug design, and can be used for the development of a new generation of Wnt pathway inhibitors, and has a great clinical application value and considerable market potential.

Five-membered heterocyclic amides WNT pathway inhibitor

The present invention discloses a compound for regulating protein kinase activity and used for treating or preventing diseases associated with protein kinases. Specifically, the present invention relates to a benzofuran pyrazole amine protein kinase inhibitor which belongs to compounds that regulate anaplastic lymphoma kinase (ALK), and provides a method of preparing such a compound and a pharmaceutical use of such a compound in the treatment or prevention of diseases associated with ALK. The inhibitor can solve the problem of the drug resistance of the first generation and the second generation of ALK inhibitors.

Benzofuran pyrazole amine kinase inhibitor

The invention provides gemcitabine derivatives shown in the following formula (I) and preparation methods thereof. The invention further relates to a pharmaceutical composition which comprising the said gemcitabine derivatives in an effective amount and a pharmaceutically acceptable excipient or additive. The invention further provides use of the said derivatives for preparing anti-tumor drugs. The compound designed by the invention is novel in structure and has a remarkable anti-tumor activity. According to the compound designed by the invention, the preparation starting materials have extensive sources and are easily obtained, the preparation method is simple and easy to operate, and the yield of the product is high, so that industrial production on a large scale is facilitated. 

Gemcitabine derivatives, compositions comprising same and pharmaceutical applications thereof

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Zhejiang, China

Yaodong Wu