China Agricultural University

Hong Guan Ltd.

Beihao Stem Cell and Regenerative Medicine Research Institute Co., Ltd.

Yao Fu

Xu Zhang

Xiao Ming Ma

Yang Zhao

Hongkui Deng

Guoshi Liu

Jingyang Guan

Songyang Yao

Haiying Yu

Yujun Yao

Dongying Lv

Shengyu Guan

Ting Zhao

Junqing Ye

Provided is a method for reducing methane production in animal stomachs by adding melatonin to gastric juice of the animal or feeding the animal with melatonin. In the method of the present disclosure, 10-7 mol/L to 10-3 mol/L of melatonin can reduce the methane production from the in vitro gastric fermentation fluid, and feeding melatonin of 8.0 to 35.0 mg/kg/day can reduce the methane production from the animal respiration from day 7 of feeding melatonin. The method of the present disclosure can reduce greenhouse gas emissions of animals, control environmental pollution and realize low-carbon farming.

Method for reducing methane production in animal stomach

Provided are chemical inducers of pluripotency (CIP) which include glycogen synthase kinase inhibitors, TGFβ receptor inhibitors, cyclic AMP agonists and S-adenosylhomocysteine hydrolase (SAH) inhibitors or histone acetylators. A method of inducing pluripotency in a partially or completely differentiated cell by using such chemical inducers of pluripotency is also provided. The method includes: (i) contacting a cell with the CIPs for a sufficient period of time to result in reprograming the cell into a pluripotent stem cell having ESC-like characteristics (CiPSC). Isolated chemically induced pluripotent stem cells (CiPSCs) and their progeny, produced by inducing differentiation of the CiPSCs, can be used in a number of applications, including but not limited to cell therapy and tissue engineering.

Methods for reprograming non-pluripotent cells into pluripotent stem cells

Growing community of inventors

Beijing, China

Yao Fu