Agency for Science, Technology and Research

Singapore Health Services Pte Ltd

Kabushiki Kaisha Topcon

Tan Tock Seng Hospital Pte Ltd

Yanwu Xu

Jiang Liu

Wing Kee Damon Wong

Jun Cheng

Beng Hai Lee

Ngan Meng Tan

Tin Aung

Fengshou Yin

Baskaran Mani

Masahiro Akiba

Tien Yin Wong

Zhuo Zhang

Shamira Asith Perera

Xinting Gao

Tock Han Lim

Xiangang Cheng

Huiying Liu

Ching-Yu Cheng

Yim-lui Carol Cheung

Augustinus Laude

Lixin Duan

The present disclosure generally relates to automated method and system for vision assessment of a subject. The method comprises: determining a set of test patterns for the subject based on a preliminary assessment of an eye of the subject; displaying the set of test patterns sequentially to the subject; collecting data on the subject's gaze in response to each test pattern displayed to the subject; and assessing vision functionality of the subject based on the collected gaze data.

Vision assessment based on gaze

A method and system are proposed to obtain a reduced speckle noise image of a subject from optical coherence tomography (OCT) image data of the subject. The cross sectional images each comprise a plurality of scan lines obtained by measuring the time delay of light reflected, in a depth direction, from optical interfaces within the subject. The method comprises two aligning steps. First the cross sectional images are aligned, then image patches of the aligned cross sectional images are aligned to form a set of aligned patches. An image matrix is then formed from the aligned patches; and matrix completion is applied to the image matrix to obtain a reduced speckle noise image of the subject.

Reducing speckle noise in optical coherence tomography images

A numerical parameter indicative of the degree of match between two retina images is produced by comparing two graphs obtained from the respective images. Each graph is composed of edges and vertices. Each vertex is associated with a location the corresponding retina image, and with descriptor data describing a part of the corresponding retina image proximate the corresponding location.

Robust graph representation and matching of retina images

A method is proposed for automatically locating the optic disc or the optic cup in an image of the rear of an eye. A portion of the image containing the optic disc or optic cup is divided into sub-regions using a clustering algorithm. Biologically inspired features, and optionally other features, are obtained for each of the sub-regions. An adaptive model uses the features to generate data indicative of whether each sub-region is within or outside the optic disc or optic cup. The result is then smoothed, to form an estimate of the position of the optic disc or optic cup.

Methods and systems for automatic location of optic structures in an image of an eye, and for automatic retina cup-to-disc ratio computation

A method is presented to obtain, from a retinal image, data characterizing the optic cup, such as data indicating the location and/or size of the optic cup in relation to the optic disc. A disc region of the retinal image of an eye, is expressed as a weighted sum of a plurality of pre-existing 'reference' retinal images in a library, with the weights being chosen to minimize a cost function. The data characterizing the cup of the eye is obtained from cup data associated with the pre-existing disc images and the corresponding weights. The cost function includes (i) a construction error term indicating a difference between the disc region of the retinal image and a weighted sum of the reference retinal images, and (ii) a cost term, which may be generated using a weighted sum over the reference retinal images of a difference between the reference retinal images and the disc region of the retinal image.

Cost-sensitive linear reconstruction based optic cup localization

A method is proposed for analyzing an optical coherence tomography (OCT) image of the anterior segment (AS) of a subject's eye. A region of interest is defined which is a region of the image containing the junction of the cornea and iris, and an estimated position the junction within the region of interest is derived. Using this a second region of the image is obtained, which is a part of the image containing the estimated position of the junction. Features of the second region are obtained, and those features are input to an adaptive model to generate data characterizing the junction.

Methods and systems for characterizing angle closure glaucoma for risk assessment or screening

Growing community of inventors

Singapore, Singapore

Yanwu Xu