Guangzhou Yunyuan Biotech Co., Ltd.

Hefei Tairui Biotechnology Co., Ltd.

Yanwen Jin

Michael Rynkiewicz

Cheng Cao

David Weaver

David T Weaver

A humanized anti-EGFR antibody L4-H3 and gene encoding the antibody are disclosed. The antibody is composed of a heavy chain and a light chain. The amino acid sequence of the heavy chain variable region is shown as positions 1-145 of SEQ ID NO: 3, the heavy chain constant region is the heavy chain constant region of the human antibody IgG1, and the amino acid sequence of the light chain is shown as SEQ ID NO: 1.

Humanized anti-EGFR antibody L4-H3 and coding gene thereof

The present invention discloses humanized anti-epidermal growth factor receptor antibodies, which have favorable binding activity (the binding affinity being 6.13&#xd7;10mol/L) and are able to inhibit the growth and migration of tumor cells. The present invention also discloses the preparation methods and uses of the antibodies.

Anti-epidermal growth factor receptor antibodies and uses thereof

The present invention discloses humanized anti-epidermal growth factor receptor antibodies, which have favorable binding activity (the binding affinity being 5.09&#xd7;10mol/L) and are able to inhibit the growth and migration of tumor cells. The present invention also discloses the preparation methods and uses of the antibodies.

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Beijing, China

Yanwen Jin