Roche Palo Alto LLC

Hoffmann-la Roche Inc.

F. Hoffmann-la Roche Ag

Yansheng Zhai

Clara Jeou Jen Lin

Amy Geraldine Moore

Michael Patrick Dillon

Matthew C Lucas

Francisco Xavier Talamas

Sharada Shenvi Labadie

Shaoqing Chen

Johannes Cornelius Hermann

Andreas Kuglstatter

Nidhi Arora

Jutta Wanner

Eva Papp

Counde O'Yang

Ryan Craig Schoenfeld

Christine E Brotherton-Pleiss

Marzia Villa

Shelley K Gleason

Clara Jeou Lin

Compounds of the formula I or II: wherein X, m, Ar, Rand Rare as defined herein. The subject compounds are useful for treatment of IRAK-mediated conditions.

Pyrazolo[1,5a]pyrimidine derivatives as IRAK4 modulators

Compounds of formula 1 are modulators of P2X3 useful for the treatment of pain and genitourinary, gastrointestinal, and respiratory disorders: wherein

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This invention relates to compounds which are alpha-1 receptor agonists, preferably alpha-1A/L receptor agonists, and which are represented by Formula I:wherein m, A, X, Y, R, R, R, Rand Rare as defined in the specification; or individual isomers, racemic or non-racemic mixtures of isomers, or pharmaceutically acceptable salts or solvates thereof. The invention further relates to pharmaceutical compositions containing such compounds, methods for their use as therapeutic agents, and methods of preparation thereof.

Method for detecting a gram-negative bacterial autoinducer molecule

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Nutley, NJ, United States of America

Yansheng Zhai