Neurofx, Inc.

Chemigen

Other

Du, Yansheng, Dr.

Yansheng Du

Keith Leonard March

Brian H Johnstone

Junyi Liu

Zhizhong Ma

Jirun Peng

Martin R Farlow

Ruyu Du

Methods of producing stem cell conditioned media to treat mammalian injuries or insults. In at least one embodiment of a method of producing a stem cell conditioned media of the present disclosure, the method comprises the steps of culturing at least one stem cell in a first cell culture medium, replacing some or all of the first cell culture medium with a second cell culture medium and further culturing the at least one stem cell in the second cell culture medium, and collecting a quantity of the second cell culture medium after a culture duration, wherein the quantity of the second cell culture medium contains a cell culture byproduct effective to treat a mammalian insult or injury.

Stem cell conditioned media and methods of using the same

Methods of producing stem cell conditioned media

Disclosed is the use of the compounds represented by formula (I) in the preparation of a medicament against tumor angiogenesis, wherein Rand Rare each independently C-Calkylidene group or C-Calkenylidene group; Aand Aare each independently aryl, isoaryl, or aryl or isoaryl optionally substituted by halogen, &#x2014;CN, &#x2014;NO, &#x2014;OH, &#x2014;SH, &#x2014;OR, &#x2014;SR, &#x2014;R, &#x2014;R&#x2014;OR, &#x2014;C(O)R, &#x2014;S(O)R, &#x2014;S(O)R, &#x2014;NRR, &#x2014;C(O)OR, &#x2014;C(O)NRR, &#x2014;O(O)CR, &#x2014;S(O)CRor &#x2014;NR(O)CR, wherein Ris C-Calkyl, Rand Rare each independently hydrogen, C-Calkyl, aryl or substituted aryl; and X and Y are each independently oxygen; and the compound of formula (I) does not include phenethyl caffeate. 

Use of phenethyl caffeate derivatives in the preparation of a medicament against tumor angiogenesis

Methods of producing stem cell conditioned media to treat mammalian injuries or insults. In at least one embodiment of a method of producing a stem cell conditioned media of the present disclosure, the method comprises the steps of culturing at least one stem cell in a first cell culture medium, replacing some or all of the first cell culture medium with a second cell culture medium and further culturing the at least one stem cell in the second cell culture medium, and collecting a quantity of the second cell culture medium after a culture duration, wherein the quantity of the second cell culture medium contains a cell culture byproduct effective to treat a mammalian insult or injury. In another embodiment, the step of culturing comprises culturing the at least one stem cell in EGM2MV.

Methods of producing stem cell conditioned media to treat mammalian injuries or insults

A pharmaceutical composition containing a mitochondrial electron transport chain enhancer (or an antioxidant) and a compound of formula (I) shown in the specification. This pharmaceutical composition can be used to treat neurodegenerative disorders.

Combination therapy using coenzyme Q10 and a caffeic acid-derived ester

This invention relates to caffeic acid derivatives and improving viability of neuronal cells by contacting neuronal cells by caffeic acid derivatives as shown in the specification.

Caffeic acid derivatives and their use in improving neuronal cell viability

A method for producing caffeic acid phenyl ester and its analogues, which includes the steps of: (i) reacting, in a solvent, a salt of a compound of formula (II) with an organic halide having the formula X&#x2014;R-Ain the presence of an iodide catalyst having the formula M-I to produce caffeic acid phenyl ester or its analogue, wherein A1, R1, Q, Y, X, R2, and M are defined herein; and (ii) isolating the caffeic acid phenyl ester or its analogue from the solvent.

Method for producing caffeic acid phenyl ester and its analogues

A method for producing stem cell conditioned media for treatment of neurological insults is provided herein. By providing for the culture of adipose stem cells, and collecting the supernatants thereof, the supernatants have been shown to effect biological activity in preventing neural death when the supernatants are administered to a patient that has or is about to be subjected to a neural insult.

Growing community of inventors

Westfield, IN, United States of America

Yansheng Du