Chinese Academy of Sciences

Yunnan University

Yanping He

Liumeng Yang

Yongtang Zheng

Hongbin Zhang

Chengrun Tang

Wei Ding

Yumeng Wu

Yufang Zhang

Ruomei Rui

Jiangyuan Wang

Yiming Li

Disclosed is a pyrimidinone-containing compound represented by formula I, a preparation method thereof, a pharmaceutical composition, and an application thereof. The pyrimidinone-containing compound of the present disclosure can be used as HIV-1 inhibitor and can be also used in the treatment of human immunodeficiency virus infection. 

Pyrimidinone-containing compound, preparation method thereof, pharmaceutical composition and application thereof

Disclosed is a DACOs-type NNRTIs amino acid ester derivative, a preparation method thereof, a pharmaceutical composition, and an application thereof. The structure of the DACOs-type NNRTIs amino acid ester derivative is represented by formula (I). The DACOs-type NNRTIs amino acid ester derivative represented by formula (I) can be used as HIV-1 inhibitors and for the preparation of a drug for treating and/or preventing immunodeficiency viruses. 

DACOS type NNRTIS amino acid ester derivative, preparation method thereof, pharmaceutical composition, and application thereof

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Kunming, China

Yanping He