Koninklijke Philips Corporation N.V.

Bracco Suisse Sa

Yannick Bohren

Jeffry E Powers

William Tao Shi

Ralf Seip

Jean-Marc Paul Robert Hyvelin

Emmanuel Jean-Marie Gaud

Feng Yan

Marcel Arditi

Scott William Dianis

Ebeline Bihel

Francois Tranquart

Jeffry Earl Powers

Jean-Marc Paul Hyvelin

François Tranquart

A therapeutic ultrasound system transmits a staggered or interleaved pattern of therapy beams for use in sonothrombolysis and other Vascular Acoustic Resonators (VAR) mediated therapy. The inventive technique minimizes VAR, e.g. microbubble, destruction due to adjacent beams, ensures uniform sonication of the targeted region by filling in the spaces between the beams in subsequent passes, and further provides a means for bubble replenishment to maximize the clot lysis from ultrasound. The technique is also applicable to diagnostic ultrasound, VAR mediated drug delivery and blood brain barrier opening.

Interleaved beam pattern for sonothhrombolysis and other vascular acoustic resonator mediated therapies

Ultrasonic sonothrombolysis systems to produce two acoustic pressure levels of insonation during stroke therapy, mid/high acoustic pressure insonation directed to the site of a blood clot where microbubbles are present to induce microbubble-mediated blood clot lysis, and low acoustic insonation directed to the region surrounding the site of the blood clot where microbubbles are present to stimulate microvascular reperfusion of the surrounding tissue. The systems simultaneously produce blood clot lysis at the site of an occlusion and stimulate reperfusion of tissue affected by the occlusion.

Devices and methods for the ultrasound treatment of ischemic stroke

Growing community of inventors

Plan-les-Ouates, Switzerland

Yannick Bohren