Centre National De La Recherche Scientifique

Centre Hospitalier Régional Universitaire De Lille

Université Sciences Technologies Lille

Université De Droit Et Santé De Lille

Nagoya University

Inserm (institut National De La Sante Et De La Recherche Medicale)

Université Lille 1 - Sciences Et Technologies

Inserm

Yann Guerardel

Daniel Poulain

Boualem Sendid

Ken Kitajima

Nadine Francois

Francis Megraud

Hitochi Sawada

Jonathan Ferrand

A method for the in vitro diagnosis of an invasive fungal infection by MALDI-TOF mass spectrometry. The method involves, providing a liquid biological sample from a mammal, said biological sample containing, in particular, proteins and/or lipids and/or salts and/or polysaccharides and/or oligosaccharides and/or monosaccharides capable of forming complexes with said proteins and/or lipids and/or salts; treating said sample with biological liquid so as to extract said polysaccharides and/or oligosaccharides and/or monosaccharides; determining, by MALDI-TOF mass spectrometry, whether or not there is present among said extracted polysaccharides, oligosaccharides and/or monosaccharides, at least one given compound of interest coming from said fungal microorganism and chosen from polysaccharides, oligosaccharides and monosaccharides; and deducing, if said given compound of interest is present in said sample, that said mammal is suffering from an invasive fungal infection.

In vitro diagnostic method for an invasive fungal infection using MALDI-TOFF mass spectrometry

Growing community of inventors

Ronchin, France

Yann Guerardel