Atreca, Inc.

Leland Stanford Junior University

The United States Government As Represented by the Department of Veterans Affairs

Nanostring Technologies, Inc.

Yann Chong Tan

William H Robinson

Wayne Volkmuth

Gary Withey

Shaun M Lippow

Daniel Eric Emerling

Jeremy Sokolove

Jeff DeFalco

Tito Serafini

Jessica Finn

Norman Michael Greenberg

Vera Huang

Fengling Liu

Amy Manning-Bog

Alexander Scholz

Nikhil Vad

Jeff Defalco

Provided herein are antibodies that bind to tumor tissue through a binding interaction with an extracellular RNA-protein complex. Such antibodies are used in methods of inducing an immune response and methods of inhibiting tumor cell growth. Additionally provided are methods of producing such antibodies.

Antibodies that bind tumor tissue for diagnosis and therapy

Disclosed herein are compositions and methods for sequencing, analyzing, and utilizing samples such as single samples. Also disclosed herein are compositions and methods for matching together two or more sequences from a sample. Also disclosed herein are compositions and methods for expressing and screening molecules of interest.

Identification of polynucleotides associated with a sample

Provided herein are methods and compositions for analyzing nucleic acids associated with single cells using nucleic acid barcodes. According to some embodiments, a method for producing one or more polynucleotides of interest comprises: obtaining a plurality of RNAs associated with one or more samples, wherein the samples are obtained from one or more subjects, each RNA is associated with a single sample, and the RNAs associated with each sample are present in a separate reaction volume; adding an adapter molecule to the RNAs associated with each sample, wherein the adapter molecule is generated using an enzymatic reaction and comprises a universal priming sequence, a barcode sequence, and a binding site; and incorporating the barcode sequence into one or more polynucleotides associated with each sample, thereby producing the one or more polynucleotides of interest.

Analysis of nucleic acids associated with single cells using nucleic acid barcodes

The present disclosure provides methods for optimizing barcode design for multiplex DNA sequencing. Also disclosed are DNA barcodes optimized for use with particular sequencing technologies.

DNA barcodes for multiplexed sequencing

Growing community of inventors

Palo Alto, CA, United States of America

Yann Chong Tan