Momenta Pharmaceuticals, Inc.

Yanjie Jiang

Zachary Shriver

Corinne Bauer

James Eric Anderson

Peter James Ahern

Xiangping Zhu

Jonathan C Lansing

Cuihua Liu

Xiao-Jin Xu

Shiming Dong

Xianping Zhu

Methods for analyzing, selecting, characterizing or classifying compositions of a co-polymer, e.g., glatiramer acetate are described. The methods entail analysis of pyro-glutamate in the composition, and, in some methods, comparing the amount of pyro-glutamate present in a composition to a reference standard.

Analysis of amino acid copolymer compositions

Methods of analyzing glatiramer acetate (GA) or a polymeric precursor thereof are provided. The methods can include determining a level of one or more diethylamide-modified amino acids in a sample comprising GA or a polymeric precursor thereof, and selecting at least a portion of the sample based on the assessment of the one or more diethylamide-modified amino acids in the sample.

Evaluation of copolymer diethylamide

Methods for analyzing, selecting, characterizing or classifying compositions of a co-polymer, e.g., glatiramer acetate are described. The methods entail analysis of pyro-glutamate in the composition, and, in some methods, comparing the amount of pyro-glutamate present in a composition to a reference standard. In some cases, the methods entail treating the co-polymer with pyro-glutamate aminopeptidase to cleave N-terminal pyro-glutamate residues.

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North Chelmsford, MA, United States of America

Yanjie Jiang