Adama Agan Ltd.

Adam Agan Ltd.

Yaniv Barda

Sima Mirilashvili

Shmuel A Baron

Bijukumar Gopinathan Pillai

Bhavinkumar P Hamirani

Bhoopal Meka

Sreedevi Mannam

Avihai Yacovan

Doron Pappo

Carl Recsei

Aviad Mandabi

A process for preparing, 1,1,3-trioxo-1,2-benzothiazole-6-carboxamide of formula (I) comprising: (a) oxidizing 2,5-dimethyl-benzenesulfonamide of formula (II) in the presence of an oxidizing agent to receive 2-sulfamoyl-terephthalic acid of formula (III); (b) converting the formed 2-sulfamoyl-terephthalic acid of formula (III) to receive 2-sulfonoyl-terephthalic acid derivative of formula (IV); and (c) reacting the resulting 2-sulfamoyl-terephthalic acid derivative of formula (IV) with ammonia (NH) or ammonium containing-salt; wherein R represents OR′ or CI and R′ represents a branched or non-branched C-Calkyl.

Process for preparing 1,1,3-trioxo-1,2-benzothiazole-6-carboxamide

The present subject matter relates to a process for separating compound (I) from a mixture comprising compound (I). The present subject matter also relates to a process for separating compound (I) from a mixture comprising compound (I) and compound (II).

Separation of phenol isomer

A process for preparing, 1,1,3-trioxo-1,2-benzothiazole-6-carboxamide of formula (I) comprising: (a) oxidizing 2,5-dimethyl-benzenesulfonamide of formula (II) in the presence of an oxidizing agent to receive 2-sulfamoyl-terephthalic acid of formula (III); (b) converting the formed 2-sulfamoyl-terephthalic acid of formula (III) to receive 2-sulfamoyl-terephthalic acid derivative of formula (IV); and (c) reacting the resulting 2-sulfamoyl-terephthalic acid derivative of formula (IV) with ammonia (NH) or ammonium containing-salt; wherein R represents OR' or CI and R&#x2032; represents a branched or non-branched C-Calkyl.

A process for preparing, 1,1,3-Trioxo-1,2-benzothiazole-6-carboxamide of formula (I) comprising: reacting 2-chloro-sulfonyl-terephthalic acid dialkyl ester of formula (II) with ammonia (N H) or ammonium containing-salt; wherein R represents a branched or non-branched C-Calkyl.

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Rehovot, Israel

Yaniv Barda