Konkuk University Industrial Cooperation Corp

Hlb Science Inc.

Yangmee Kim

Seung-Hyun Lee

Yeong Min Park

Dasom Jeon

In Duk Jung

The present invention provides: a peptide having antibacterial activity; a composition for preventing or treating sepsis comprising same; and an antibacterial composition. More specifically, the peptide according to the present invention has the excellent effects of not only suppressing the growth of bacteria but removing endotoxins derived from bacteria, thus exhibiting an excellent therapeutic effect on sepsis, and thus can be usefully used to prevent or treat sepsis. In addition, the peptide according to the present invention has selectively excellent antibacterial activity against Gram positive/negative bacteria, and thus can be usefully used in an antibacterial composition for Gram-positive/negative bacteria, or to prevent or treat various infectious diseases caused by Gram-positive/negative bacteria. Furthermore, the peptide according to the present invention exhibits excellent resistance against proteolytic enzymes, and is highly stable, and thus is expected to be utilized in various forms, such as a pharmaceutical composition, a cosmetic composition, a food composition, a health food composition, a feed composition, and a quasi-drug composition.

Polypeptide having antibacterial activity, composition for preventing or treating sepsis comprising same, and antibacterial composition

The present invention relates to an antimicrobial peptide having an improved antibacterial effect through glutamic acid substitution and, more specifically, to a use of the antimicrobial peptide as an active ingredient in an antibacterial pharmaceutical composition, a food additive, a feed additive, an antiseptic composition, and an antibacterial quasi-drug composition. Not only does the antimicrobial peptide of the present invention exhibit significant antibacterial activity against gram-negative bacteria, but it also exhibits a significant synergistic effect when combinedly treated with antibiotics which have strong antibacterial activity only against gram-positive bacteria and has no or low antibacterial activity against gram-negative bacteria, thereby exhibiting excellent antibacterial effects on gram-positive bacteria,andbacteria among gram-negative bacteria, and antibiotic-resistant strains thereof.

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Seoul, South Korea

Yangmee Kim