Zhejiang Hisun Pharmaceutical Co., Ltd.

Yanghui Guo

Hua Bai

Taishan Hu

Lei Chen

Jian Chai

Yue Zhang

Hegeng Wei

Yingqiu Wu

Junhui Zhou

Qingfeng Cai

Xuan Yang

Guoping Jiang

Yili Ding

Lingwei Bai

Shibao Yang

Qingyan Yan

Weiwei Liao

Fei Long

Xiangui Huang

Lichen Meng

Provided are a tetrahydroisoquinoline derivative, a preparation method therefor and an application thereof in medicine. In particular, provided are a tetrahydroisoquinoline derivative represented by general formula (I), a preparation method therefor and a pharmaceutically acceptable salt thereof as well as use thereof as a therapeutic agent, in particular as an angiotensin II type 2 receptor (ATR) antagonist, wherein definitions of substituent groups in the general formula (I) are the same as definitions in the description. 

Tetrahydroisoquinoline derivative, preparation method therefor and use thereof

The present invention relates to a disaccharide intermediate and a synthesis method thereof, relates to the chemical pharmaceutical field, and more specifically relates to a method for preparing a disaccharide segment of a key intermediate for chemically synthesizing heparin and heparinoid compounds. Disclosed are a new disaccharide intermediate and three methods for synthesizing the disaccharide intermediate, that is, compounds of a formula (4) and glucopyranose protected by different anomeric carbon are made to react in the presence of an active agent, to obtain the disaccharide intermediate. According to the technical solutions of the present invention, synthetic raw materials are easy to obtain, have a mild reaction condition, and are suitable for industrialized production.

Disaccharide intermediate and synthesis method thereof

The present invention relates to a process of a chemically synthetic drug, and in particular, to a new intermediate of a heparin pentasaccharide and a preparation method thereof. The process has high reaction efficiency, and an easy reaction operation. The reaction intermediate is easy to be purified, and is appropriate for an industrialization production.

Preparation of new intermediate of heparin pentasaccharide and preparation method thereof

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Zhejiang, China

Yanghui Guo