University of Illinois

Yangfeng Li

Gregory R Thatcher

Rui Xiong

Jiong Zhao

Yunlong Lu

Lauren Gutgesell

Carlo Ivan Rosales

In one aspect, the disclosure relates to relates to substituted benzothiophene analogs which are useful as selective degraders of estrogen receptor, methods of making same, pharmaceutical compositions comprising same, and methods of treating one or more clinical conditions associated with estrogen receptor, such as a cancer, including breast cancer, or osteoporosis. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

Substituted benzothiophene analogs as selective estrogen receptor degraders

Described herein are pyridinone-based compounds, derivatives thereof, and pharmaceutical formulations thereof. In some aspects, the pyridinone-based compounds, derivatives thereof, and/or pharmaceutical formulations thereof can be administered to a subject in need thereof. In some aspects, pyridinone-based compounds, derivatives thereof, and/or pharmaceutical formulations thereof can modulate an activity and/or a function of a BRD protein and/or BET protein.

Pyridinone-based epigenetic modifiers and uses thereof

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Chicago, IL, United States of America

Yangfeng Li