Suzhou Ark Biopharmaceutical Co., Ltd.

Cqc Intime Testing Technology Co., Ltd.

Yang Zhou

Gang Zou

Haiqing Yuan

Cheng Peng

Zhen Jim Wu

Zhaoxiong Cai

Shaoyun Zhang

Xiashi Lv

Danbin Li

Xiaogang Lai

Jie Wang

Yixin Zhu

Xiyu Song

Mei Zhang

Mengfei Qian

Yanfei Wang

Qing Xu

Teng Feng

Rui Cui

Jian Han

Chaojun Gong

The present disclosure provides an elastase inhibitor prodrug and use thereof, being a compound of formula I or a pharmaceutically acceptable salt, ester, isomer or solvate thereof, prodrugs or isotopically labeled compound. Compared with the compound 52 (control example) in WO 2018/175173 A1, the compound disclosed herein has the advantages of high pulmonary exposure and long half-life. The prodrugs of the present disclosure significantly increase the concentration and residence time of the active compound (control example) in the lungs with significant improvements in pharmacokinetics in vivo compared to the control example.

Elastase inhibitor prodrug and use thereof

An organic wastewater treatment method based on a multi-element co-doping TiOnano photocatalytic material includes preparing a sulfur-titanium dioxide mixture, hydrothermally reacting the sulfur-titanium dioxide mixture with copper chloride, ammonia, strong alkali, a transition metal salt and the like, reacting the resulting reaction product with hydrofluoric acid, then performing temperature programming thermal treatment in air to obtain the multi-element co-doping TiOnano photocatalytic material, and then treating organic wastewater with the multi-element co-doping TiOnano photocatalytic material under the irradiation of visible light. The organic wastewater treatment method is efficient and rapid, safe and environmental-friendly, can thoroughly degrade many types of organic pollutants, ammonia nitrogen and the like, and does not cause secondary pollution; furthermore, the adopted multi-element co-doping TiOnano photocatalytic material can be regenerated and recycled only by simple calcination, and the cost is inexpensive.

Organic wastewater treatment method based on multi-element co-doping TiO2 nano photocatalytic material

Compositions containing the compound of general formula I: are disclosed. The compositions be used to prevent or treat hepatitis B virus infection.

Dihydroisoquinoline compound

A compound of general formula I: is disclosed. The compound be used to prevent or treat hepatitis B virus infection.

Growing community of inventors

Suzhou, China

Yang Zhou