General Electric Company

University of Alberta

Centre for Probe Development and Commercialization

Bhandari, Krishna, Hari

Doschak, Michael

Yang, Yang

Yang Yang

Tao Wu

Bruce Fletcher Johnson

Michael James Rishel

Randall Lee Carter

John Fitzmaurice Valliant

Karin Ann Stephenson

Anup Sood

Michael Doschak

Krishna Hari Bhandari

Mark Christopher Patrick Darey

Mark Christopher Darey

Described herein is insulin, an insulin-like growth factor, parathyroid hormone, a fragment of parathyroid hormone, or a parathyroid hormone related protein that includes at least one bone targeting moiety, wherein the bone targeting moiety is covalently bonded to the peptide. Also described herein are the methods of making these compositions that prevent or treat conditions associated with bone loss and preventing bone fractures, and/or the inability to initiate de novo bone turnover and stimulate bone fracture repair.

Parathyroid hormone, insulin, and related peptides conjugated to bone targeting moieties and methods and making and using thereof

An embodiment of the invention comprises method of imaging a target site comprising administrating ligand of Formula I complexed toTc wherein Rand Rare independently an alkyl or cycloalkyl; Ris and alkyl; X is CO or SO; Y is (CH2), CH, (OCHCH)(NHCHCH)and (OCHCHCH), or a combination thereof; Z is linker group capable of conjugating to a vector; and n is an integer between 0 and 10.

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The present teachings provide methods that enable the preparation and purification of radioiodinated vectors without the need for HPLC purification, as well as novel precursors which include biotin-like substituents useful in such methods.

Biotin stannane for HPLC-free radioiodination

Growing community of inventors

Edmonton, Canada

Yang Yang