University of Texas System

Immune Targeting, Inc.

Yang-Xin Fu

Hua Peng

Jerry W Shay

Jinming Gao

Zhijian Chen

Gang Huang

Ilgen Mender

Zhaohui Wang

Hua Wang

Anli Zhang

Min Luo

Haocheng Cai

Jingya Guo

The invention provides novel fusion proteins of Interleukin 15 and prodrugs, and compositions and methods of preparation thereof, useful in treating various diseases and disorders (e.g., hyperplasia, solid tumor or hematopoietic malignancy).

Interleukin 15 fusion proteins, and compositions and therapeutic methods thereof

Disclosed herein are methods of treatments with a telomerase-mediated telomere-targeting drug, 6-thio-2'-deoxyguanosine (6-thio-dG), checkpoint inhibitors and/or radiation therapy for treating cancers. Leads to tumor regression in innate and adaptive immune-dependent manners in syngeneic and humanized mouse cancer models.

Sequential treatment of cancers using 6-thio-dG, checkpoint inhibitors and radiation therapy

In some aspects, the present disclosure provides vaccine compositions comprising an antigen and a diblock copolymer wherein the diblock copolymer is pH responsive. In some embodiments, these compositions activate the STING and/or the interferon receptor pathways. In some embodiments, the diblock copolymer hits a pKa from about 6 to about 7.5. Also provided herein are methods of treatment using these compositions to treat an infectious disease or cancer.

Sting activating nanovaccine for immunotherapy

Growing community of inventors

Dallas, TX, United States of America

Yang-Xin Fu