Rutgers, the State University of New Jersey

Memorial Sloan Kettering Cancer Center

University of Bonn

The Rockefeller University

Yang Wu

Thomas Tuschl

Gunther Hartmann

Roger A Jones

Barbara L Gaffney

Dinshaw J Patel

Manuel Ascano, Jr

Winfried Barchet

Pu Gao

Thomas Zillinger

Yizhou Liu

Roger Jones

The present disclosure provides, among other things, compounds comprising cyclic dinucleotides containing a 2',5' linkage useful in the design of research tools, as research tools, and as therapeutic modalities such as enzyme modulators.

Compositions and methods for altering second messenger signaling

The invention relates to compositions, methods, kits, and assays related to the use and/or exploitation of isomers of cGAMP as well as the structure of the enzyme cGAS.

The present disclosure provides, among other things, novel cyclic-GMP-AMP (cGAMP) analogs, mimics, mimetics and variants, and compositions and kits thereof; methods of using the compounds as described herein for treating cancer, and immune disease, disorders, or conditions; methods of using the compounds as described herein for modulating cGAS and STING; and methods of designing or characterizing a cGAS modulator.

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New York, NY, United States of America

Yang Wu