Salesforce Com, Inc.

University of California

Salesforce, Inc.

Yang Su

Nate Botwick

Pedram Razavi

Kevin Gibbs

Rajeev Nayak

Diana Berlin

Scott Lee Goodfriend

Julie Tung

Bret Taylor

Patrick Linehan

Shrey Banga

Lindsey Simon

Drew Hamlin

Nikrad Mahdi

Andy Chung

Sophia Westwood

Bin Liu

Scott Bidlingmaier

Christopher R Behrens

Namkyung Lee

Andrew Michael Chung

John Arlan Brock

Christopher Masterson

Merwan Hade

Justin Edmund

Norris Lee

Anh Khuc

Ben Cronin

Matthew Chan

David Engelberg

Kyle Meyer

Christopher De La Iglesia

Blake T Aftab

Daniel W Sherbenou

Dan Willhite

Dave Engelberg

In various embodiments human anti-CD46 antibodies that are internalizing and enter tumor cells via the macropinocytosis pathway are provided, as well as antibody-drug conjugates (ADCs) developed from these antibodies for diagnostic and/or therapeutic targeting of CD46-overexpressing tumors.

Macropinocytosing human anti-CD46 antibodies and targeted cancer therapeutics

Disclosed herein are methods of treating a subject having a cancer characterized by a modification at biomarker 1q21, which comprises administering to the subject a therapeutically effective amount of an anti-CD46 antibody.

Anti-CD46 antibodies and methods of use

Disclosed herein are system, method, and computer program product embodiments for providing a security model to customizable live applications in a cloud collaboration platform. The security approach may dedicate a frame to each live application, serving the frame from a different domain than a document in which the live application is embedded. This approach ensures that more stringent security requirements may be required of the live application and allows the data presented to the live application to be narrowly tailored. The security model may further leverage sandbox attributes and content-security policies to restrict the behavior of sandboxed and non-sandboxed live applications in accordance with best security practices.

Security model for live applications in a cloud collaboration platform

Disclosed herein are system, method, and computer program product embodiments for providing offline capabilities to customizable live applications in a cloud collaboration platform. The cloud collaboration platform may provide offline functions and a data application programming interface to devices connecting to the cloud collaboration platform. The offline capabilities allow devices to store data related to documents and customizable live applications in a local cache. The offline capabilities retrieve data from and store modifications to data within the local cache. The cloud collaboration platform may subsequently process the changes and determine if conflicts arise, resolving conflicts where appropriate and possible. The cloud collaboration platform may then determine a final state for a record, return the final state to the devices, and update the local caches.

Offline capabilities for live applications in a cloud collaboration platform

The present disclosure relates to an engineered antibody that co-engages a cell type-selective (or specific) antigen (guide) and a signaling receptor (effector) on a target cell. In some instances, the engineered antibody is capable of modulating a signaling pathway on a target cell. In other embodiments, an engineered antibody of the present disclosure is administered to a subject for the treatment of a disease or condition.

Engineered antibodies and uses thereof

Disclosed herein are system, method, and computer program product embodiments for providing a data model application programming interface ('API') to customizable live applications in a cloud collaboration platform. The cloud collaboration platform provides data storage, a data model, and an API to embedded third-party live applications to allow the live applications to securely create, store, and access data within the cloud collaboration platform. The data model allows records stored in the cloud collaboration platform to sync independently, merge intelligently, and function offline.

Data model API for live applications in a cloud collaboration platform

Display screen or portion thereof with graphical user interface

Disclosed herein are system, method, and computer program product embodiments for providing a rich text box to customizable live applications in a cloud collaboration platform. The rich text box component may extend styles and functions performed within a document editor in the cloud collaboration platform to customizable live applications. This extension ensures a consistent user experience where the behavior of text-editing in live application mirrors that of the standardized document editor. Additional functionality, such as mentions and auto-completions, may be performed by the rich text boxes embedded in a live application without adding to the code base of the live application, complicating design decisions, and/or circumventing the security requirements of a live application.

Rich text box for live applications in a cloud collaboration platform

This invention provides antibodies directed against a highly specific and previously unrecognized marker for cancerous cells. In certain embodiments an isolated antibody or fragment thereof that specifically binds human placentally expressed ALPP and/or ALPPL2, but not ALPL and ALPI that are expressed outside the placenta is provided as well as immunoconjugates comprising such antibodies.

Tumor-specific payload delivery and immune activation using a human antibody targeting a highly specific tumor cell surface antigen

Disclosed herein are system, method, and computer program product embodiments for providing a data model application programming interface to customizable live applications in a cloud collaboration platform. The cloud collaboration platform allows third-party live applications to securely create, store, and access data within the cloud collaboration platform. The data model allows records stored in the cloud collaboration platform to sync independently, merge intelligently, and function offline.

Growing community of inventors

San Francisco, CA, United States of America

Yang Su