Jinan University

Yang Ni

Dan Zhang

Yang Yu

Xiuqi Bao

Xinsheng Yao

Lin Li

Hao Gao

Caixía Zang

Yuanpeng Zheng

Provided are a series of crocins compounds and related pharmacological applications thereof in prevention and treatment of Alzheimer's disease. The series of crocins compounds are obtained by taking the Chinese herb, namelyEllis, as a raw material and separating same by means of various methods. The compounds playing a role in preventing oxidative injury caused by hydrogen peroxide (HO) and excitatory amino acid injury caused by L-glutamic acid are screened out by in-vitro cell experiments. The results show that the crocins compounds have good effect in preventing cell injury caused by HOand L-glutamic acid. The compounds have good effect in preventing and treating Alzheimer's disease due to the fact that significant rise of oxidative stress and excitatory amino acid is a key factor for nerve injury in Alzheimer's disease, and have broad development and application prospect.

Crocins compounds and uses thereof

A composition, and a crocins active site extracted fromEllis, mainly comprising the following ingredients: crocetin di-&#x3b2;-D-gentiobioside, crocetin-&#x3b2;-D-glucopyranosyl-&#x3b2;-D-gentiobioside, crocetin di-&#x3b2;-D-glucopyranoside, 13Z-crocetin di-&#x3b2;-D-gentiobioside, neocrocin B, crocetin mono-&#x3b2;-D-gentiobioside, 13Z-crocetin-8-O-&#x3b2;-D-gentiobioside, 13Z-crocetin-8'-O-&#x3b2;-D-gentiobioside, and crocetin mono-&#x3b2;-D-glucopyranoside. Pharmacological experiment results show that the crocins active site can effectively improve learning and memory injuries in mice induced by scopolamine and amyloid &#x3b2; protein.

Composition, crocins active site, and uses thereof

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Guangdong, China

Yang Ni