Joulwatt Technology (hangzhou) Co., Ltd.

Adlai Nortye Biopharma Co., Ltd.

Zhejiang University

Yang Lu

Ji Wang

Pan Li

Donghui Yang

Yuancheng Ren

Xunwei Zhou

Pitleong Wong

Yue Ji

Nanhai He

Qiaodong Wen

Hua Lei

Yu Zhou

Zhiyong Yu

Guangtao Han

Yufeng Chen

Weiwei Ge

Zhiying Huang

Quan Gan

Canfeng Liu

Weihuai Wang

Beidi Xu

Kaixuan Chen

Qingchong Qiu

Enguang Feng

Youping Wang

Dandan Chen

Shengfeng Jiang

The present invention provides compounds of Formula (I) or (II), pharmaceutical compositions thereof, and methods of using compounds of Formula (I) or (II) to prevent and/or treat immune-related disorders.

Highly active sting protein agonist compound

The present disclosure relates to a lateral double-diffused transistor and a manufacturing method of the transistor. The transistor comprises: a substrate; a well region and a drift region both located in the top of the substrate, a source region located in the well region, and a drain region located in the drift region; a first dielectric layer located on a surface of the drift region; a first field plate layer located above the drift region and covering a first portion of the first dielectric layer; a second dielectric layer covering a surface of part of the first field plate layer and stacked on a surface of a second portion of the first dielectric layer; a second field plate layer located on a surface of the second dielectric layer, comprising at least one contact channel. According to the present disclosure, the transistor increases breakdown voltage and reduces on-state resistance.

Lateral double-diffused transistor and manufacturing method thereof

Provided is a compound represented by formula (I) and a pharmaceutical composition thereof, as well as a method for using a compound represented by formula (I) to prevent and/or treat immune-related disorders.

PD-L1 antagonist compound

The present application relates to a system and a method for effectively screening and assessing agents for tumor immunotherapy, which includes assessment for the effects of target cells, non-target cells, and tumor infiltration. The system and method of the present application can be used to comprehensively and systematically assess the effectiveness and safety of the agent against tumor immune cells.

System and method for screening and assessing agents for tumor immunotherapy

The present disclosure application relates to a construction method of a yeast display library (YSD), specifically to a construct for a yeast display library, an expression vector, a host cell and a construction method and use thereof. The yeast display library provided by the present application has high transformation efficiency and rich diversity.

Construction of fully human antibody yeast display technique

Disclosed are a transistor structure for electrostatic protection and a method for manufacturing the same. The transistor structure comprises: a doped region in a substrate; field oxide layers; a first N-type well region, a P-type well region and a second N-type well region in the doped region and spaced in sequence; a first polycrystalline silicon layer and a second polycrystalline silicon layer covering part of the P-type well region; a first N+ region and a first P+ region respectively formed in the first N-type well region and the second N-type well region second P+ region and the second N+ region are close to the first N+ region and the first P+ region, respectively. The structure may change a current path under forward/reverse operation; thus, a device keeps a good electrostatic protection capability and high robustness.

Transistor structure for electrostatic protection and method for manufacturing same

A method and a system for establishing a metal interconnection layer capacitance prediction model are disclosed. The method for establishing the metal interconnection layer capacitance prediction model includes: extracting capacitance data of metal interconnect layer capacitors of different sizes by using a post simulation tool and establishing a relationship formula between capacitance value and size of the metal interconnect layer capacitors; separately extracting relationship data between voltage and capacitance value of the metal interconnect layer capacitors and between temperature and capacitance value of the metal interconnect layer capacitors by using a process device simulation tool, and add the relationship data to the relationship formula; and establishing a simulation model in accordance with the relationship formula of capacitance value, size, voltage and temperature. The method has improved modeling speed and reduced circuit design cycle. The model thereof can be applied to the analysis of the small size capacitors with reliability.

Method and system for establishing metal interconnection layer capacitance prediction model

The present invention relates to a compound represented by formula I, a pharmaceutical composition containing the compound of formula I, a method for inhibiting indoleamine 2,3-dioxygenase, and its use in medicine. 

Indoleamine 2,3-dioxygenase inhibitors and use of same in medicine

A circuit and a method for detecting a current zero-crossing point, and a circuit and method for detecting a load voltage are disclosed. The circuit for detecting current zero-crossing point includes: a load power supply circuit, a voltage-dividing resistor, a transistor switch, a zero-crossing detection circuit; the load power supply circuit includes: a load, a diode, and a transformer; one end of a primary winding of the transformer is connected with the operating voltage input terminal, the other end of the primary winding of the transformer is connected with a first end of the transistor switch and a first end of the voltage-dividing resistor, a second end of the voltage-dividing resistor and a second end of the transistor switch are connected with the ground, the load voltage is controlled by the transistor switch.

Circuit and method for detecting current zero-crossing point and circuit and method for detecting load voltage

A circuit and a method for detecting a current zero-crossing point, and a circuit and method for detecting a load voltage are disclosed. The circuit for detecting current zero-crossing point includes: a load power supply circuit (), a voltage-dividing resistor (), a transistor switch (), a zero-crossing detection circuit (); the load power supply circuit () includes: a load (), a diode (), and an inductor (); one end of the load power supply circuit () is connected with the operating voltage input terminal, the other end of the load power supply circuit () is connected with a first end of the transistor switch () and a first end of the voltage-dividing resistor (), a second end of the voltage-dividing resistor () and a second end of the transistor switch () are connected with the ground, the load voltage is controlled by the transistor switch (), the voltage-dividing terminal of the voltage-dividing resistor () is connected to a signal input terminal of the zero-crossing detection circuit (), the zero-crossing detection circuit () is used to determine whether the current of the diode () crosses zero to obtain the on time of the diode (), and the circuit for detecting load voltage uses the on time of the diode () and the on time of the transistor switch () to obtain the load voltage. The circuits are simple, but with high detection efficiency and low cost.

Circuit and method for detecting current zero-crossing point, and circuit and method for detecting load voltage

A metering pump with a special-shaped cavity comprising a housing, a rotor and two cover plates. The housing is a cylinder with a special-shaped surface inner cavity formed by combining two circular arc surfaces with two non-circular arc surfaces and a planar surface, an inlet and an outlet. The rotor comprises a rotor body and two pairs of combined sliding plates. The housing is matched with the cover plates for constituting a sealed cavity. When the rotor rotates, the non-circular arc surface of the special-shaped surface inner cavity can enable the two pairs of the combined sliding plates to slide in a cross manner so as to suck in fluid from the inlet and press out the fluid from the outlet. When the rotor rotates one cycle, four standard volumes are formed in a cavity body and the equal quantity of the fluid flows by the cavity body.

Growing community of inventors

Hangzhou, China

Yang Lu