Realtek Semiconductor Inc.

Kimberly-clark Worldwide, Inc.

Vacdiagn Biotechnology Co., Ltd

Yang Huang

Shi-Meng Zou

Bin Shao

David William Koenig

Aimin He

Yong Liu

Corey Thomas Cunningham

Qi Liu

Mary Kay Foegen

Jianqing Xu

Xiaoyan Zhang

Bao Trong Do

Douglas Robert Hoffman

Lu Wang

Jonathan Hofmekler

Mingquan Gao

Jiahao Sun

Cesar A Morales

Yi-Fan Zhang

The present invention provides a recombinant viral vector, an immunogenic composition containing the same, and the use thereof. The recombinant viral vector comprises a polynucleotide encoding a fusion peptide of CD4 helper T cell epitopes, the epitope fusion peptide comprising a cytomegalovirus epitope and/or an influenza virus epitope. The epitope fusion peptide and the recombinant viral vector provided by the present invention can improve the level of cellular immune response to a target immunogen, particularly to a weak immunogen, and overcome the immune tolerance of immune system to an antigen, particularly to a tumor antigen or an infection-related antigen. The products of the present invention are suitable for enhancing the efficacy of vaccines.

Recombinant viral vector, immune composition containing same, and use thereof

The present invention discloses a Bluetooth mesh network system having quick provisioning mechanism that includes an infrared control apparatus and nodes. The infrared control apparatus generates a provisioning activation infrared signal. Each of the nodes receives the provisioning activation infrared signal and generates a group key according to predetermined group number information thereof to perform communication according to the group key based on a Bluetooth mesh network communication protocol.

Bluetooth mesh network system and provision method having quick provisioning mechanism

The present invention discloses a Bluetooth mesh network system having wake-up management mechanism that includes a control node and low power nodes. The control node broadcasts a wake-up parameter setting packet at broadcast time spots based on a broadcast period. Each of the low power nodes receives the wake-up parameter setting packet to be operated in a wake-up management mode to configure a start time spot, a time length and a period interval length of a wake-up period that is synchronous among the low power nodes accordingly. The control node further transmits data corresponding to the low power nodes in the wake-up period and the low power nodes is operated in a wake-up state within the wake-up period to receive the data from the control node and is operated in a sleep state outside of the wake-up period.

Bluetooth mesh network system and connection method having wake-up management mechanism

The present invention discloses a Bluetooth mesh network system having a communication range extending mechanism that includes a plurality of nodes and a provisional node. The provisional node is configured to transmit a connection setting packet to the nodes to control the nodes to establish a coded PHY connection between each two of the nodes such that a packet error rate is smaller than a threshold value when the nodes perform communication when a physical distance between each two of the nodes is larger than a maximum non-coded-PHY communication distance, in which when the nodes establish a non-coded-PHY connection and the physical distance is larger than the maximum non-coded-PHY communication distance, the packet error rate is larger than the threshold value.

Bluetooth mesh network system and connection method having communication range extending mechanism

The present invention discloses a low power dissipation Bluetooth mesh network system and a communication method thereof. The Bluetooth mesh network system includes a friend node and a lower power node. The friend node operates as a proxy server terminal to perform a proxy server broadcast. The lower power node operates as a proxy client and establishes a connection with the friend node based on a proxy protocol when the proxy server broadcast is received and identified. The friend node further filters out an invalid packet unrelated to the low power node and stores a valid packet related to the low power node so as to transmit the valid packet to the low power node when the low power node switches from a sleep status to a wakeup status.

Low power dissipation Bluetooth mesh network system and communication method

The present invention discloses a Bluetooth mesh network system having unprovisioned communication mechanism that includes a delivering node and a receiving node. The delivering node generates a beacon signal having identification information that is not a key and performs broadcast communication. The receiving node receives the beacon signal and performs identification and processing under a network communication protocol to execute a command corresponding to the beacon signal.

Bluetooth mesh network system and communication method having unprovisioned communication mechanism

The present disclosure discloses a Bluetooth mesh network system having power management mechanism that includes low power nodes and a friend node. The friend node operates a part of the low power nodes under a first connection mode to establish a one-to-one connection with the friend node under a connection protocol. The friend node operates the other part of the low power nodes under a second connection mode to establish a many-to-one connection based on a broadcast protocol. The friend node sets a mode operation time threshold value and accumulates a mode connection time for each of the low power nodes. When the mode connection time of one of the low power nodes that operates under one of the first connection mode and the second connection mode reaches the corresponding mode operation time threshold value, the one of the low power nodes switches to operate under the other one of the first connection mode and the second connection mode.

Bluetooth mesh network system and connection method having power management mechanism

Farnesol analogs, along with their related products (e.g., treatment compositions, wipes, absorbent articles, etc.) and their methods of formation, are provided. The farnesol analog includes a hydrophilic end group (e.g., a hydroxyl end group or a carboxylic acid end group) attached to farnesol via a covalent linkage (e.g., an ester group or an ether group).

Water soluble farnesol analogs and their use

Disclosed are a fusion peptide of CD4 helper T cell epitopes, a nucleic acid encoding the same and an immunogenic composition comprising the same. The epitope fusion peptide comprises a cytomegalovirus epitope and an influenza virus epitope. The epitope fusion peptide can substantially improve the level of cellular immune response to a target immunogen, particularly a weak immunogen, and is an effective means for overcoming the immune tolerance of immune system to an antigen, particularly to a tumor antigen or an infection-related antigen, and is suitable for efficiently enhancing the efficacy of vaccine.

Fusion peptides of CD4 helper T cell epitopes and vaccines thereof

The present invention discloses a Bluetooth mesh network system having control authority sharing mechanism that includes an original provisioner node and at least one newly added provisioner node. The original provisioner node stores control authority information related to a Bluetooth mesh network, controls the Bluetooth mesh network accordingly and performs a control authority broadcast. The newly added provisioner node receives the control authority broadcast and establishes connection with the original provisioner node according to a connection protocol. The newly added provisioner node further requests the control authority information from the original provisioner node so as to control the Bluetooth mesh network after receiving the control authority information from the original provisioner node.

Bluetooth mesh network system and control method having control authority sharing mechanism

Methods for adjusting the solubility of a botanical oil in water, along with the resulting modified botanical oil and related products (e.g., treatment compositions, wipes, absorbent articles, etc.) are provided. In one embodiment, the method includes reacting the botanical oil to form a reactive product (e.g., having a hydroxyl group); and attaching a hydrophilic end group (e.g., a carboxylic acid, a carboxylic acid salt, a sugar, etc.) on the reactive product to form a modified botanical oil. The modified botanical oil generally, in most embodiments, has a greater solubility in water than the botanical oil (e.g., a solubility in water of about 10 grams per 100 grams of water or greater, such as completely soluble in water). The botanical oil includes, in one particular embodiment, an essential oil, such as those essential oil that include at least one terpene compound.

Water soluble essential oils and their use

Lateral-flow assay and time-resolved fluorescence technologies provide a sensitive tool for detecting norovirus particles in a sample. A flow-through assay device employs norovirus and norovirus G2 antibodies. The lateral-flow assay includes a conjugate pad having conjugated probes. The conjugated probes are particles modified with a binding member that is configured to bind with a norovirus. The particles also have a fluorescent label. A general method of detecting the virus includes (i) preparing a sample with contaminants, (ii) processing the sample and depositing it onto the assay device, and (iii) measuring the fluorescence signal.

Devices and methods for detecting norovirus on surfaces

Formulations and wipes for imparting a sporicide to a surface are disclosed herein. To achieve the sporicidal efficacy of the product, a synergistic amount of an amine oxide surfactant and a mixture of oxidants is incorporated into the formulation. The operative sporicidal formulation contains a solvent, an amine oxide surfactant, a water soluble oxidant and a water insoluble oxidant. Typically, the formulation can contain about 0.05 to about 3.7 percent (by weight of the formulation) of an amine oxide surfactant, about 0.5 to about 4 percent (by weight of the formulation) of a water soluble oxidant, and about 0.1 to about 6 percent (by weight of the formulation) of a water insoluble oxidant.

Sporicidal formulation including amine oxide surfactant and a mixture of oxidants

The invention provides a method of preventing the spreading of influenza viruses, and the factors making up the said method, and especially provides one type of combinatorial vaccine and the immunization method thereof. Two of more influenza vaccines are inoculated by a certain sequence, and each influenza vaccine vaccines is inoculated at least once, and the inoculation take place two or more times; wherein each influenza vaccine includes one or more antigens, the immunogenic fragments thereof, or the coding genes thereof, and further includes a different antigen, the immunogenic fragments or the coding gene of the different antigen.

Growing community of inventors

Suzhou, China

Yang Huang