Chinese Academy of Sciences

Shanghai National Engineering Research Center of Digital Television Co., Ltd.

Jinan University

Haihe Biopharma Co., Ltd.

Yang Dai

Jian Ding

Meiyu Geng

Yang Liu

Zhang Zhang

Wenjun Zhang

Jun Sun

Yunfeng Guan

Dazhi He

Ge Huang

Ke Ding

Yin Xu

Jing Ai

Yao Wang

Xia Peng

Zhengchao Tu

Yanfeng Wang

Youhong Hu

Li Tan

Xiaoyun Lu

Xiaomei Ren

Yinchun Ji

Limin Zeng

Wenming Ren

Xiaocong Guan

Lang Wang

Shingpan Chan

Weiqiang Liang

An o-aminoheteroaryl alkynyl-containing compound has a structure represented by formula (I), and the compound of formula (I) has advantages of a high FGFR and RET double target inhibitory activity and a relatively low KDR activity, and the compound of formula (I) exhibits a strong inhibitory activity in a human lung cancer cell line NCI-H1581 and a gastric cancer cell line SNU16 as well as an RET-dependent sensitive cell line BaF3-CCDC6-Ret and a mutant thereof. Pharmacokinetic data shows that the o-aminoheteroaryl alkynyl-containing compound has druggability, and exhibits significant relevant inhibition of the growth of related tumors in a long-term animal model of drug efficacy and results in favorable animal condition at effective doses. 

O-aminoheteroaryl alkynyl-containing compound, preparation method therefor, and use thereof

This invention discloses a digital TV broadcast system coordinated with a broadband communication network, an information transmission network in which the broadcast system is applied, a digital TV heterogeneous network architecture, and a client terminal used in each of the above network systems. The various broadcast system architectures of the invention adopt the design concept of heterogeneous network which integrates a broadcast network with other networks, for example, a communication network, the Internet and the like, to form a heterogeneous network architecture coordinating various networks. Meanwhile, the usage in bad conditions are taken into account, and a broadcast TV system which enables uplink transmission by using a broadcast link is designed. The terminal of the invention is a terminal applicable in these heterogeneous network architectures, is capable of receiving signals transmitted from various networks, and can enable flexible receiving and access modes with a series of control means. The network system and client terminal of the invention can achieve an optimized allocation of network resources, save spectrum resources, and enable optimized transmission and management of information resources.

Digital television network structure and user terminal

Growing community of inventors

Shanghai, China

Yang Dai