International Business Machines Corporation

Yang Chuan

James L Hedrick

Dylan J Boday

Rudy J Wojtecki

Jeannette M Garcia

Yi Yan Yang

Nathaniel H Park

Zhen Chang Liang

Ashlynn Lingzhi Lee

Shaoqiong Liu

A stimulus-responsive micellar carrier, methods that may be associated with making a stimulus-responsive micellar carrier, and methods that may be associated with using a stimulus-responsive micellar carrier are disclosed. The stimulus-responsive micellar carrier comprises a cargo molecule, and a linear block copolymer having a hydrophilic block connected to a hydrophobic block by a stimulus-responsive junction moiety. The micellar carrier can be supplied to a patient body for therapeutic purposes, such as the treatment of cancerous tissue. A method of preparing or obtaining a stimulus-responsive micellar carrier may include preparing a polyethylene glycol material having an acetal end group and then preparing a block copolymer by forming a reaction mixture including the polyethylene glycol material, a cyclic carbonate monomer, and a base.

Stimulus-responsive micellar carrier

Growing community of inventors

Singapore, Singapore

Yang Chuan