Kaohsiung Medical University

China Medical University

Other

University of North Carolina at Chapel Hill

Metal Industries Research & Development Centre

China Medical University Hospital

Advpharma, Inc.

We-win Applied Bio-tech Co., Ltd.

Yang-Chang Wu

Fang-Rong Chang

Chin-Chung Wu

Ying-Chi Du

An-Shen Lin

Sheng-Chu Kuo

Tung-Ying Wu

Jai-Sing Yang

Li-Chen Chou

Mei-Chin Lu

Mann-Jen Hour

Tai-Lin Chen

Tusty-Jiuan Hsieh

Po-Wu Gean

Hong-Zin Lee

Lien-Chai Chiang

Hui-Chun Wang

Kuo-Hsiung Lee

Yi-Hong Tsai

Juan-Cheng Yang

Che-Ming Teng

Woei-Cherng Shyu

Shiow-Lin Pan

Tian-Shung Wu

Chun-Yu Chen

Suh-Hang Hank Juo

Tsong-Long Hwang

Chen-Huan Lin

Tzu-Chen Kuo

Min-Tsang Hsieh

Ling-Chu Chang

Hsin-Yi Hung

Pei-Jung Lien

Hui-Ping Hsieh

Yu-Ming Hsu

Chih-Hsin Wang

Xiaoming Yang

Chuan-Chia Sun

Sheng-Chung Yang

Bing-Hung Chen

Chen Hsieh

Yung-Fong Tsai

Liang-Mou Kuo

Yuh-Pyng Sher

Yuan-Bin Cheng

Keduo Qian

Masuo Goto

Ying-Qian Liu

Yong-Long Zhao

Liu Yang

Mei-Juan Wang

Zhi-Jun Zhang

Chih-Ya Wang

Ting-Ting Kuo

Chung Y Hsu

Chi-Ting Hsieh

Chia-Chien Lo

Da-Wei Chuang

Hsue-Yin Hsu

This invention is announcing a composition of flavonoid skeleton in the formula I or formula II compound, wherein each of the substituents is given the definition as set forth in the specification and claims. This composition has the capacity to treating or preventing a virus infection in a subject. 

Methods and compositions for inhibition of ATR and FANCD2 activation

The present disclosure relates to an ADAM9 inhibitor compound of formula (I), including salts, hydrates and stereoisomers thereof, compositions thereof, and methods of use therefor, including treating a person in need thereof with an effective amount of the compound or composition, and detecting a resultant improvement in the person's health or condition.

Composition including ADAM9 inhibitor and the use thereof

Theextract of the present invention is prepared using supercritical fluid technique, wherein the method includes steps of: (a) drying the leaves of; (b) pulverizing the leaves as particles; and (c) extracting the particles with supercritical carbon dioxide to obtain theextract. This supercriticalextract not only can decrease blood sugar level, but also promotes lipid degradation, inhibits the formation of huge lipid droplet and improves the metabolic symptoms. Accordingly, theextract further is able to be prepared as food supplement and pharmaceuticals.

Extract offrom supercritical fluid extraction for treating diabetes and metabolic disease, the preparation method and the use thereof

The present invention relates to phorbol esters from the seeds ofby a series of chromatographic processes, and compositions containing these congeners for the treatment of allergic responses.

Compositions and methods of antiallergic phorbol ester and phorbol derivatives as the main active ingredients from the seeds of aquilaria malaccensis

This invention is announcing a composition of flavonoid skeleton in the formula I or formula II compound, wherein each of the substituents is given the definition as set forth in the specification and claims. This composition have the capacity to treating or preventing a virus infection in a subject. 

Disclosed are a composition for preventing and treating atherosclerosis which includes chalcone compound. In particular, the chalcone compound bound with 2-hydroxyl in ring A and 4'-methyoxy in ring B has versatile therapeutic potentials on anti-atherosclerosis by acting as PPAR&#x3b3; inducer, p44/42 MAPK inhibitor and cell cycle blocker and does not show toxicity to human aortic smooth muscle cells (HASMCs). In addition, the chalcone compound exhibits synergistic effect with the PPAR&#x3b3; ligand (rosiglitazone) to inhibit cell proliferation and the upregulation of cyclin D1, cyclin D3, interleukin-1&#x3b2; (IL-1&#x3b2;) and interleukin-6 (IL-6) induced by oxidized low density lipoprotein (Ox-LDL).

Composition for treating atherosclerosis and a preparation method thereof

Disclosed herein are novel formyl peptide receptor 1 (FPR1) antagonists and their uses in manufacturing medicaments for the treatment and/or prophylaxis of diseases and/or disorders mediated by FPR1.

Formyl peptide receptor 1 antagonists and uses thereof

The present invention is related to novel 20-sulfonylamidine derivatives of camptothecin (1), method of synthesizing the same, and use thereof as an antitumor agent, for examples an antitumor agent for treating nasopharyngeal, lung, breast or prostate cancer.

[object Object]

Disclosed are a method for analyzing chemical profiles of components from a herbal medicine product. Components may include quinone (including rhein, sennoside A and/or aloe-emodin), stilbene containing resveratroloside, flavone including baicalin, and/or alkaloid including berberine and/or palmatine. The method includes steps of: (a) respectively chromatographing a methanol extract of product and standard(s) corresponding to the component(s) using HPLC; (b) comparing HPLC chromatogram of extract and standard(s); and (c) analyzing the chemical profiles of the product from the comparison results.

Chemical profile of detecting bioactive components of quinones, stilbenes, flavones and alkaloids

A preparation method for a water extract of the fruiting body of(ACW) is provided. The method includes steps of: (a) providing the fruiting body; and (b) boiling the fruiting body in water to obtain the water extract. This polysaccharide-rich water extract frominduces the maturation of dendritic cells, enhances T cell proliferation and INF-&#x3b3; production, and polarizes them toward the Th1 pathway. ACW can be effectively applied in cancer immunotherapy.

Disclosed is a chalcone composition for treating diabetes and metabolic syndromes. In particular, the chalcone compound bound with 2-halogen in ring A significantly decreases the blood glucose level in the in vitro anti-diabetic effect experiment. In the in vivo animal model, the leading chalcone compound can prevent the progression of diabetes and control the blood glucose level, and there is no significant difference in the gains in body weight. Throughout the seven-week administration, there are no hepatic or renal toxicity observed.

Composition for treating diabetes and metabolic diseases and a preparation method thereof

Provided is a compound of the formula I or a pharmaceutically acceptable salt, solvate or stereoisomer thereof:  

2-aryl-4-quinazolinones and their pharmaceutical compositions

New pharmaceutical compositions extracted from-are confirmed to effectively treat influenza A (HN) virus. The extraction method of the new pharmaceutical compositions mainly includes steps of: (a) extracting-with methanol to obtain a crude extract; (b) fractioning the crude extract with n-hexane-methanol to obtain a methanol extract; (c) fractioning the methanol extract with chloroform-water to obtain a chloroform extract; and (d) chromatographing the chloroform extract to obtain the pharmaceutical compositions, which can be further fractioned and chromatographed to obtain various sesquiterpene coumarins.

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Kaohsiung, Taiwan

Yang-Chang Wu