Yanfeng Zhou

Laurent Gauthier

Nicolas Gourdin

Angela Virone-Oddos

Alessandro Masiero

Marielle Chiron

Leila Sevigny

Ingo Focken

Jochen Beninga

Alexandre Tang

Sambasiva Rao

The present disclosure relates to multifunctional binding proteins comprising a first and a second antigen binding domains (ABDs) and all or part of an immunoglobulin Fc region or variant thereof, wherein the first ABD binds specifically to human BCMA and the second ABD binds specifically to human NKp46 and wherein all or part of the immunoglobulin Fc region or variant thereof bind to a human Fc-γ receptor. The disclosure also relates to methods for making said binding proteins, compositions thereof, and their uses, including the treatment or prevention of proliferative disorders, including multiple myeloma (MM).

Natural killer (NK) cell engagers binding to NKp46 and BCMA variants with Fc-engineering

Growing community of inventors

Cambridge, MA, United States of America

Yanfeng Zhou