2y-chem, Ltd.

Yanfeng Zhou

Yong Liang Liu

Lei Zhang

Xungui He

Xuezhang Wang

The present invention discloses an improved process for preparing an important intermediate of linagliptin. In particular, disclosed are a process for preparing a compound V which is an important intermediate of linagliptin and has the structure V, and an industrial process of preparing linagliptin having excellent chemical and optical purities, which is an inhibitor of dipeptidyl peptidase-4 (DPP-IV), from the compound V. The process employs a phase-transfer catalyst, is high in yield, easy and simple to handle, environmentally friendly, suitable for industrial mass production, and can be implemented by a 'one-pot process'. 

Growing community of inventors

Shanghai, China

Yanfeng Zhou