Shanghai Normal University

Zhuhai Hengqin New District Zhongzhu Zhengtai Medical Management Co., Ltd.

Yanfei Zhang

Jian Ding

Ying Chen

Yizhun Zhu

Yichun Zhu

Zhongnan Yang

Xinhua Liu

Yueling Li

Rinkiko Suguro

The invention discloses a rice temperature sensitive male sterile gene mutant tms18 and its uses. During the study of TMS18 gene, the inventors found that the changing of fertility was related to the structural integrity of the second layer of pollen outer wall. The inventors accidentally found the thermo sensitive male sterile mutant tms18. The fertility of the mutant was affected by different temperatures and can be restored under low temperature treatment. More importantly, the fertility sensitive period of the mutant was different from that of other thermo sensitive male sterile genes. This unique feature of the gene can provide a new theoretical basis and apply value for two-line hybrid rice breeding.

Rice thermo-sensitive male sterile gene mutant tms18 and uses thereof

This invention belongs to the modern pharmaceutical field of Traditional Chinese Medicine, and relates to an herbal extract of Chinese Motherwort and its application in pharmacy, which specifically relates to the crystal structure of a Chinese Motherwort extract: Leonurine, and its application in the preparation of medicine. The chemical name of the above-mentioned Leonurine is 4-guanidino-1-)butyl 4-hydroxy-3,5-dimethoxybenzoate. The invention by specific methods prepares leonurine as 6 kinds of crystals with different crystal forms. Specifically, there are six different structures of leonurine sulfate crystals, two of them are hydrate, two are anhydrous crystal form, one is methanol solvate, one is ethanol solvate. The leonurine crystal forms of this invention can applicate in preparing medicine such as insulin sensitizer, hypoglycemic and lipid-lowering drugs. The above mentioned insulin sensitizers are particularly useful in treating insulin resistance syndrome, and the above mentioned lipid-lowering drugs are useful in the treatment of disorders of lipid metabolism, hyperlipidemia and their complications.

Leonurine crystal and use thereof in preparation of insulin sensitizer, hypoglycemic drug and lipid-lowering drug

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Shanghai, China

Yanfei Zhang