Suzhou Ark Biopharmaceutical Co., Ltd.

Yanfei Wang

Gang Zou

Yang Zhou

Haiqing Yuan

Cheng Peng

Zhen Jim Wu

Zhaoxiong Cai

Mengfei Qian

The present disclosure provides an elastase inhibitor prodrug and use thereof, being a compound of formula I or a pharmaceutically acceptable salt, ester, isomer or solvate thereof, prodrugs or isotopically labeled compound. Compared with the compound 52 (control example) in WO 2018/175173 A1, the compound disclosed herein has the advantages of high pulmonary exposure and long half-life. The prodrugs of the present disclosure significantly increase the concentration and residence time of the active compound (control example) in the lungs with significant improvements in pharmacokinetics in vivo compared to the control example.

Elastase inhibitor prodrug and use thereof

Growing community of inventors

Suzhou, China

Yanfei Wang