University of Utah Research Foundation

Biomimetic Therapeutics, LLC

Yanchun Liu

Glenn D Prestwich

Xiao Zheng Shu

Samuel E Lynch

Kelly R Kirker

Hans K Kestler

Leslie Wisner-Lynch

Yi Luo

Steven D Gray

Janice Gray, Legal Representative

Hao Li

Leslie A Wisner-Lynch

The invention provides compositions and methods for treatment of tendon and ligament injuries and/or repair of damaged tendons and ligament. The invention provides compositions comprising a biocompatible matrix and platelet-derived growth factor (PDGF).

Platelet-derived growth factor composition and methods for the treatment of tendon and ligament injuries

Platelet-derived growth factor compositions and methods for the treatment of tendon and ligament injuries

Described herein are crosslinked compounds useful in numerous treatments. Described herein are methods of making crosslinked compounds via (1) the oxidative coupling of two or more thiol compounds or (2) by the reaction between at least one thiol compound with at least one thiol-reactive compound.

Crosslinked compounds and methods of making and using thereof

Described herein are compounds such as macromolecules that have been modified in order to facilitate crosslinking and methods of making and using thereof.

Modified macromolecules and associated methods of synthesis and use

Described herein are composites that inhibit or reduce adhesion between two or more tissues. Also described herein are methods of using the composites.

Anti-adhesion composites and methods of use thereof

Described herein are compounds such as macromolecules that have been modified in order to facilitate crosslinking by introduction of at least one hydrazide-reactive group and/or aminooxy-reactive group, and methods of making and using thereof for scar-free wound healing, for delivering bioactive agents or living cells, for preventing adhesion after a surgical procedure or for bone and cartilage repair. The macromolecule can be an oligonucleotide, a necleic acid, a polypeptide, a lipid, a glycoprotein, a glycolipid, a polysaccharide, a protein or a synthetic polymer, preferably a glycosaminoglycan like hyaluronan.

Modified macromolescules and associated methods of synthesis and use

Described herein are crosslinked compounds useful in numerous treatments. Described herein are methods of making crosslinked compounds via (1) die oxidative coupling of two or more thiol compounds or (2) by the reaction between at least one thiol compound with at least one thiol-reactive compound.

Growing community of inventors

Franklin, TN, United States of America

Yanchun Liu