Tasly Pharmaceutical Group Co., Ltd.

Yanchuan Li

Jing Wang

Xiaohui Ma

Yonghong Zhu

He Sun

Yanyong Liu

Shuiping Zhou

Min Han

Wangyi Zhou

Disclosed is an application of substituted cinnamamide derivatives in the preparation of anti-anxiety medications, the substituted cinnammide derivatives are compounds having the structure of formula (I) or pharmaceutically acceptable salts thereof, wherein, Ris &#x2014;H, &#x2014;OH, &#x2014;F, &#x2014;Cl, &#x2014;Br, &#x2014;I, &#x2014;OCH, &#x2014;OCF, &#x2014;OCHF, &#x2014;OCHF, &#x2014;CF, &#x2014;CHF, &#x2014;CHF, &#x2014;CH, &#x2014;CHCH, &#x2014;CFCH, &#x2014;CN, &#x2014;NO, &#x2014;NHor &#x2014;COOR; Ris H, C-Clinear alkyl, C-Cbranched alkyl, C-Ccyclic alkyl, C-Chydroxyalkyl or a N-substituted piperazine-derived group; or Ris a group forming with adjacent Y a tetrahydropyrrolyl group, a piperidyl group or a cyclohexanimido group. 

Application of substituted cinnamamide derivatives in preparation of anti-anxiety medication

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Tianjin, China

Yanchuan Li