Sichuan Research Institute of Nature Drugs

Bsh Hausgerate Gmbh

Yancheng Wu

Chao Wang

Quan Yuan

Ming Zhao

Xinrong Chen

Shiqi Peng

Taigang Mo

Xingwei Li

Ping Ye

Hui Kuang

Fei Lu

Zongwen Fan

Xuli Cui

The present invention relates to a new kind of heavy metal chelating agents and a preparation process and uses thereof. The said heavy metal chelating agents are expressed in &agr;-&lsqb;D(&plus;)glucose-1-yl-amino&rsqb;-&bgr;3-mercapto-(S)-propanoic acid (abbreviated to NGP,I) and/or N,N&prime;-di&lsqb;D(&plus;)glucose-1-yl&rsqb;-L-cystine (abbreviated to NGCD,II). In the process of preparation, glucose and cysteine are reacted with a base, with a reducing agent, and the obtained products are acidified to give NGP,I, which can be used in and/or as drugs, health foods and food additives for accelerating the excretion of heavy metals including Pb, Cd, Hg, Al, Sb, As, etc. The structural feature of the compounds of the present invention is that they contain glucose and cysteirie in their molecules. Compared with the heavy metal-excreting drugs of prior art, the compounds of the present invention have four advantages, namely suitability for oral administration, high ability to accelerate the excretion of heavy metals, high selectivity and less toxicity.

Heavy metal chelating agent for oral administration, its synthesis and its uses in medicine and health protection

Growing community of inventors

Sichuan, China

Yancheng Wu