International Business Machines Corporation

Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

China University of Mining and Technology

Centaurus Biopharma Co., Ltd.

Lianyungang Runzhong Pharmaceutical Co., Ltd.

Shenzhen University

University of Science and Technology Beijing

Beijing Medisan Technology Co., Ltd

Shouyao Holdings (beijing) Co., Ltd.

Yuliang Li

Harbin Medisan Pharmaceutical Co., Ltd.

Yan Zhu

Chang Lu

Hongbin Liu

Hua Wang

Fan Yang

Hui Zhang

Yong Peng

Yongxin Han

Hong Luo

Huting Wang

Lei Wang

Heping Xie

Qian Ma

He Huang

Yin Xia

Yang Ju

Lin Chen

Yuandong Hu

Dengming Xiao

Wei Shang

Zhe Wang

Hongjiang Xu

Ling Yang

Feng Gao

Yibo Zhang

Yu Wang

Bo Liu

Li Li

Jeffrey D Taft

Zhe Xiang

Na Zhao

Lei Ji

Yinghui Sun

Yi Bo Zhang

Fansheng Kong

Ping Pan

Zhangyu Ren

Peng Liu

He Wang

Qiong Wu

Fei Liu

Xin Tian

Zhi Gao

Jin Cui

Xiaodong Nie

Jijun Li

Jin Z Zhou

Changbing Wan

Jinxin Song

Ruyun Yu

Xianxing Shang

Chun Ying

Ying Sun

Yizhong Zhu

Dandan Li

Limin Yang

Chuanyu Zhang

Hao Yin

Lulu Wang

Yuanyuan Huang

Ailing Wang

Mingxin Wang

Jinai Liu

Jianqiu Tang

Ruiyu Zhao

Qin Yan

Zanping Wang

Pan Ping

Shousong Cao

Weinan He

Yeliu Wang

Feng Pu

Yongheng Wei

Yao Qin

Yu Fei

Yong Zhang

The present invention relates to a iminosulfanone compound represented by formula (I) as a bromodomain protein inhibitor and a pharmaceutically acceptable salt thereof and to a preparation method, pharmaceutical composition, and medical use thereof.

Iminosulfanone compound as bromodomain protein inhibitor and pharmaceutical composition and medical use thereof

The present invention mainly relates to the field of information technology, and specifically to a method and system for cryptographic attribute-based access control supporting dynamic rules. In the system, the protected object is stored in an encrypted form, only the access request satisfying the access policy in attribute-based access control can be authorized to decrypt the object, which ensures that the access to data in an unsecure environment can be authorized according to a security policy, and supports dynamic policy and real-time authorization of attributes. The method and system for cryptographic attribute-based access control supporting dynamic rules in this invention have already separated from traditional encryption system framework, are totally new attribute-based access control model, method and system supporting cryptographic determination, can achieve more secure, diversified, dynamic and flexible access authorization, are suitable for large-scale organizations or information systems, and can be applied to the environments such as Cloud computing, grid computing, and distributed computing.

Method and system for cryptographic attribute-based access control supporting dynamic rules

An automatic coal mining machine and a fluidized coal mining method are provided. A first excavation cabin is configured to cut coal seam to obtain raw coal and to be transported to a first coal preparation cabin for separating coal blocks from gangue. Then, the obtained coal blocks are transported to a first fluidized conversion reaction cabin. The first fluidized conversion reaction cabin converts the energy form of the coal block into liquid, gas or electric energy, which is transported to a first energy storage cabin for storing. Coal mining and conversion are carried out in underground coal mines, so it is not necessary to raise coal blocks to the ground for washing and conversion, thereby reducing the transportation cost of coal, improving the utilization degree of coal, and avoiding the pollution of the ground environment caused by waste in the mining and conversion process.

Automatic coal mining machine and fluidized coal mining method

A mining machine applicable to fluidized mining and a mining method therefor are provided herein. A microwave transmitting mechanism, a liquid jet drill rod and a cutter-head are arranged at the head of a first excavation device of the mining machine. The ore body in front is first processed by the microwave transmitting mechanism and the liquid jet drill rod to reduce the strength of the ore body, which facilitates subsequent mining of the ore body, lowers the hardness requirements of the cutter-head, and reduces the wearing of the cutter-head. With this mining machine mining the ore body, the mined ores can be directly converted, under the ground, into resources in the easily transportable form, without transporting the ore to the surface for conversion, which saves the cost of transporting the ore to the surface.

Mining machine applicable to fluidized mining of ore bodies and mining method

A mine field layout method suitable for fluidized mining of coal resources is provided. A main shaft and an air shaft are provided in the mine field, the bottom of the main shaft is located in the shallow horizontal coal seam zone, and the bottom of the air shaft is located in the deep horizontal coal seam zone. The horizontal main roadways are arranged at two boundaries along the strike of the coal seam, and inclined main roadways are arranged at two boundaries along the dip direction of the coal seam. Connecting roadways are located inside the mine field and are in communication with the horizontal main roadways. In the coal mining stage, the coal resources can be converted into the fluidized energy product and/or electricity by an unmanned automatic mining machine.

Mine field layout method suitable for fluidized mining of coal resources

A method and system for group-oriented encryption and decryption that supports the implementation of the designation and revocation functions of decryption users in a large-scale group. During the encryption, the system acquires a corresponding aggregate function according to an encryption mode; acquires any selected subset S and public parameters, and outputs an aggregate value of the subset S; generates a ciphertext of to-be-transmitted information according to the public parameters, a to-be-transmitted message and the aggregate value; acquires the encryption mode and the subset S comprised in the received ciphertext, operates the subset S and an identity of a current decryptor according to the encryption mode, and outputs a new subset S'; acquires an aggregate function corresponding to the encryption mode during the decryption; outputs an aggregate value of the new subset S&#x2032;; and decrypts the received ciphertext according to the public parameters and the aggregate value, so as to obtain the to-be-transmitted information.

Method and system for group-oriented encryption and decryption with selection and exclusion functions

The disclosure relates to a crystal of an aniline pyrimidine compound of trifluoroethyl substituted indole and a salt thereof as an EGFR inhibitor, specifically relates to a crystal of a compound represented by formula I, a crystal of monomethyl sulfonate of the compound represented by formula I or a crystal of dimethyl sulfonate of the compound represented by formula I, and further relates to a method for preparing the crystal, a crystalline composition comprising the crystal, or a pharmaceutical composition comprising the crystal or a crystalline composition thereof, and a medical use thereof. 

Crystal of aniline pyrimidine compound of trifluoroethyl substituted indole and salt thereof

The present disclosure relates to aniline pyrimidine derivatives or pharmaceutically acceptable salts thereof as EGFR inhibitors, specifically relates to compounds represented by formula (I) or pharmaceutically acceptable salts, pharmaceutical compositions, the method and uses thereof for treating EGFR mediated diseases. 

N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(3-methyl-2-OXO-2,3-dihydro-1h-benzo[d]imidazol-1-yl)pyrimidin-2-yl)amino)phenyl)acrylamide hydrochloride as an inhibitor of epidermal growth factor receptor activity

The present invention relates to a quinazoline derivative shown in formula (I) and a preparation method therefor, a pharmaceutical composition comprising the compound shown in formula (I), and an application of the compound in preparing drugs for curing and preventing tumors. The compound of the present invention can irreversibly prevent EGFR phosphorylation, and effectively depress signal transduction of cancer cells, and accordingly has higher anti-tumor activity in vitro and in vivo. 

Quinazoline derivative and preparation method therefor

The invention provides a compound represented by formula (I) which may modulate a kinase, and a pharmaceutical composition thereof, as well as the method for preventing or treating a protein kinase mediated disease or condition. 

Kinase modulating compounds, compositions containing the same and use thereof

The present disclosure relates to a compound of formula I, a pharmaceutical composition thereof and the use thereof as an anti-tumor drug. 

Compound of camptothecin and preparation and use thereof

A method for determining travel time of a vehicle on a road, wherein the vehicle is operable within a mobile communication network, comprising: collecting historical communication events of a mobile user in order to obtain travel samples, wherein the historical communication events indicate when the mobile user travelled along a monitored road; determining a cell handover sequence from the historical communication events; determining from the cell handover sequence, one of more road segments of the monitored road; determining the travel time of the one or more road segments according to the travel time samples; selecting, for an undetermined road segment of the monitored road for which the real-time travel time is not determined from the collected historical communication events, a candidate mobile user that is most likely to appear on the undetermined road segment; actively positioning the candidate mobile user to obtain positioning information; and returning to the step of collecting communication events of a mobile user currently on a monitored road with the active positioning as one communication event for the candidate mobile user, to determine the real-time travel time of the undetermined road segment.

Method and apparatus for traffic management

Disclosed are a glycine reuptake inhibitor and the use thereof. The glycine reuptake inhibitor is a compound of formula I, or isomers, pharmaceutically acceptable salts or solvates thereof, wherein R1 is one or more groups selected from hydrogen, halogen, C1-6 alkyl, C1-6 alkoxy, nitro, cyano, amino, hydroxyl, C1-6 haloalkyl, and C1-6 haloalkoxy; R2 is selected from hydrogen, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, and C1-6 haloalkoxy; and each of R3 and R4 is independently selected from hydrogen, halogen, C1-6 alkyl, C1-6 alkoxy, nitro, cyano, amino, hydroxyl, C1-6 haloalkyl, and C1-6 haloalkoxy. 

Glycine reuptake inhibitor and use thereof

A method for selecting a channel for an access point (AP) in a Wireless Local Area Network (WLAN). The method includes the AP receiving network conditions of APs within the sensing range of a terminal sent by the terminal, and the AP selecting a channel based on the received network conditions. By forwarding the network conditions of other APs which can be detected by the terminal, the method of the present invention enables an AP to select a channel from the view of a terminal to avoid conflicts at the terminal, thereby improving the available bandwidth of the terminal, and giving a better experience to users.

Method, access point and terminal for selecting channel in wireless local area networks

A method and system for determining the position of a moving wireless communication device, the method comprising: recording moving path of the wireless communication device in cells of a cellular wireless communication network; recording moving path and GPS information of a GPS wireless communication device moving in the cellular wireless communication network in cells of the cellular wireless communication network; determining the GPS wireless communication device whose moving path matches with the moving path of the wireless communication device; and determining the position of the wireless communication device based on the GPS information of the matching GPS wireless communication device.

Method and system for determining position of moving wireless communication

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Beijing, China

Yan Zhu