Chinese Academy of Sciences

Guangzhou Yidai Pharmaceutical Co., Ltd.

Sericultural &agri-food Research Institute Guangdong Academy of Agricultural Sciences

Oral Subsidiary Sun Yat-sen University Hospital

Guangzhou Imd Therapeutics Co., Ltd.

Guangzhou Xiaopeng Motors Technology Co., Ltd.

Yan Zhang

Yong Xu

Xiaoqian Xue

Ping Li

Hua Wang

Rui Wang

Xiaofeng Huang

Xishan Wu

Mingwei Zhang

Yuanyuan Deng

Guang Liu

Zhencheng Wei

Xiaoyu Luo

Pengfei Zhou

Zhihao Zhao

Yudan Shi

Long Zhao

Xuchao Jia

Ming Song

Xiaojun Tang

Zhihao Li

Huapeng Guo

Provided are a benzidine compound and an application thereof, the benzidine compound having the structure as shown in formula I below. Further provided are a pharmaceutically acceptable salt, isomer, racemate, prodrug co-crystal complex, hydrate, and solvate of the compound, as well as an application thereof in the preparation of a drug for the treatment or prevention of RORγ-regulated diseases; more importantly, such a compound can also be used in the preparation of a drug for the treatment of inflammation, immune diseases, cancer and neurological diseases.

Benzidine compound and application thereof

The present invention relates to the technical field of natural medicines, and in particular to a triterpenoid compound with an effect of improving glucose and lipid metabolism disorders, and preparation and application thereof. A novel triterpenoid compound was obtained by separation fromL. for the first time in the present invention. Studies on a mouse primary hepatocyte model and a 3T3-L1 preadipocyte model show that the novel triterpenoid compound in the present invention has activity of regulating glucose and lipid metabolism, and after combination with known triterpenoid compound Momordicoside G, the activity of regulating glucose and lipid metabolism is significantly higher than that of a single compound at the same dose, indicating that the novel triterpenoid compound and a complex thereof in the present invention can be used to improve glucose and lipid metabolism disorders and provide a new way for diabetes treatment.

Preparation and application of triterpenoids with effect of improving glucose and lipid metabolism disorders

Provided is a non-antibody binding protein binding to PD-1 receptor which has a sequence as shown in SEQ ID NO:1 and its analogues. Also provided is use of the non-antibody binding protein in the preparation of a formulation for treating PD-1 pathway related diseases.

Non-antibody binding proteins binding to PD-1 receptors and uses thereof

The present invention relates to the technical field of medicinal chemistry, and in particular discloses a 2-oxo-1,2-dihydrobenzo[cd]indole compound and use thereof. The compound and pharmaceutically acceptable salt, isomer, racemate, prodrug, co-crystallized complex, hydrate, and solvate thereof can effectively inhibit the BET bromodomain receptor, and can be used for preparing a medicine for treating cancers, cell proliferative disorders, inflammatory diseases, and autoimmune disorders, sepsis, and viral infections.

2-oxo-1,2-dihydrobenzo[cd]indole compound and use thereof

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Guangzhou, China

Yan Zhang