Wisconsin Alumni Research Foundation

Syracuse University

The State University of New York

Yan-Yeung Luk

Nicholas Lawrence Abbott

Christopher John Murphy

Karen A Simon

Chang-Hyun Jang

Sean Francis Campbell

Li-Lin Cheng

Dacheng Ren

Matthew Lee Tingey

Deepali Prashar

Sri Kamesh Narasimhan

Preeti Sejwal

Eric Falcone

Guirong Wang

DaWei Cui

Debjyoti Bandyopadhyay

Synthetic disaccharide hydrocarbons (DSHs) that reactive bacterials swarming motility and inhibit bacterial adhesion and biofilm formation. A library of DSHs were tested in several experiment for the impact on variouspopulations and compared against existing compounds to determine efficacy and utility. Certain DSHs were also to determine the ability to clear bacteria in a mouse pneumonia model.

Synthetic disugar hydrocarbons as natural analogs to control microbial behaviors

The present invention relates to a non-amphiphile-based water-in-water emulsion composition. The non-amphiphile-based water-in-water emulsion composition includes a water-soluble polymer, a non-amphiphilic lyotropic mesogen encapsulated by the water-soluble polymer; and water. In one embodiment, the non-amphiphilic lyotropic mesogen includes, without limitation, a lyotropic chromonic liquid crystal, and more specifically disodium cromoglycate (DSCG). In another embodiment, the water-soluble polymer can include, without limitation, a polyacrylamide, a polyol, a polyvinylpyrrolidone, a polysaccharide, or a water-soluble fluoride-bearing polymer. The present invention also relates to a porous hydrogel made with the use of the non-amphiphile-based water-in-water emulsion. The present invention further relates to using the emulsion and hydrogel for various applications.

Non-amphiphile-based water-in-water emulsion and uses thereof

A library of unnatural squarylated homoserine lactones (SHLs) and squarylated lactones that bear potential to modulate biofilm formation in Gram negative bacteria. At low concentrations (&#x2dc;200 &#x3bc;M), these small molecules inhibit biofilm formation of. Moreover, these compounds are not toxic up to 300 &#x3bc;M and do not significantly attenuategrowth. The SHLs have potential to disperse established biofilm and demonstrate an enhanced reduction (&#x2dc;50%) of the maximum biofilm thickness by use of SHLs during biofilm growth.

Squarylated lactones inhibitors for bacterial biofilm formation

A system and method for preventing protein aggregation is developed by covalent modification of proteins with organic molecules that can preserve the native protein folding. Proteins are covalently modified with sugar alcohols or cyclodextrins (organic Kosmotropes) or other small molecule drugs by water-driven bioorganic reactions in water. In the water-driven bioorganic reactions, the reagent is stable in water and can modify lysine residues or cysteine residue of a protein at physiological conditions with high yield and fast rate. Proteins and antibodies will be modified by non-natural sugar alcohols. As a result, the efficacy of protein drugs (reduction in aggregation and enzymatic degradation, and increase in blood stream life time) may be improved.

Method of covalently modifying proteins with organic molecules to prevent aggregation

Liquid crystal compositions that exhibit little or no toxicity with respect to cells include liquid crystals with chemical functional groups such as fluorine atoms, fluorophenyl groups, or difluorophenyl groups. Liquid crystals with little or no toxicity to cell lines may be added to cell culture media or added to components used in cell culture media. Cells may be grown in cell culture media that includes liquid crystals that exhibit little or no toxicity to cells.

Liquid crystals with reduced toxicity and applications thereof

A method for preparing a metallized surface that possesses gradients in surface topography includes obliquely depositing a metal from a metal source onto a surface of a support. The surface of the support includes a first end, a second end, and a region between the first and second ends. The second end of the surface is located nearer to the metal source than is the first end, and the metal is deposited onto the first end of the surface at a first angle of incidence and the metal is deposited onto the second end of the surface at a second angle of incidence. The first angle of incidence is greater than the second angle of incidence, and the metal is deposited onto the region between the first and second ends at angles of incidence that vary over the region to produce the metallized surface with gradients in surface topography. The angles of incidence are measured from the normal of the support.

Surfaces with gradients in surface topography

The invention provides liquid crystal switching devices, liquid crystal cells made from the switching devices, and electrooptical cells made from the switching devices. The invention further provides methods for methods for changing the orientation of a liquid crystal in a liquid crystal switching device. The liquid crystal switching devices are constructed from a redox-active material supported by a substrate and a liquid crystal having a salt dispersed therein disposed atop the redox-active material.

Growing community of inventors

Manlius, NY, United States of America

Yan-Yeung Luk