Jiangsu Atom Bioscience and Pharmaceutical Co., Ltd.

Guangxi University

Yan Yang

Pengfei Li

Dongfang Shi

Xi Cheng

Jie Gu

Shuangfei Wang

Changjin Fu

Jianghua Zhu

Min Zhang

Hainong Song

Weiwei Gong

Fan Wu

He Zhou

Wenqing Jin

Lei Zhan

Binggui Huang

Cuisheng Xu

Fei Ban

The invention discloses compounds for treatment or prevention of liver diseases. The compounds are compounds represented by a formula (I) or (II), optical isomers or pharmaceutically acceptable salts of the compounds. The compounds and optical isomers or pharmaceutically acceptable salts of the compounds can be applied to preparation of drugs for treatment or prevention of liver diseases.

Compound for treatment or prevention of liver diseases

The present invention belongs to the field of medicinal chemistry. Specifically disclosed is a class of URAT1 inhibitors for promoting uric acid excretion, which are compounds as represented by the structure of formula (I) or pharmaceutically acceptable salts thereof. Experiments show that the compounds provided by the present invention have a very good inhibitory effect on the transport of uric acid by hURAT1 in HEK293 transfected cells, and that such compounds have a good application prospect in the treatment of hyperuricemia or gout. 

URAT1 inhibitor for promoting uric acid excretion

Growing community of inventors

Zhenjiang, China

Yan Yang