Five Prime Therapeutics, Inc.

Yan Wang

Lewis T Williams

Jeffrey T Finer

Stephen Kohl Doberstein

Kevin Hestir

Shannon Marshall

Kalyani Penta

Hongbing Zhang

Srinivas Kothakota

Loriane Masuoka

The invention provides pharmaceutical polypeptide compositions that promote proteoglycan synthesis, and promote the activity of chondrocyte cells, thereby treating arthritis. Methods of providing these compositions to treat arthritis are also provided.

Compositions for treating arthritis comprising HG1023575 polypeptide

Pharmaceutical polypeptide compositions promote the survival of cardiac cells, recruit cardiac cells to the cardiac area, stimulate the differentiation of cardiac cells, stimulate the proliferation of cardiac cells, and promote the activity of cardiac cells, thereby treating cardiac conditions. Methods of providing these compositions to the cardiac area include catheterization and direct injection. In preferred embodiments, the compositions comprise one of more of the following growth factors: EGF, bFGF, cardiotrophin-1, thrombin, PDGF-BB, amphiregulin, epiregulin, HB-EGF, TGFalpha, betacellulin, heregulin alpha, NRG-1-beta1-HRG-beta1, FGF 9.

Compositions comprising FGF-9 and betacellulin and methods for treating cardiac conditions

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Redwood City, CA, United States of America

Yan Wang