The Scripps Research Institute

International Business Machines Corporation

Tsinghua University

Peking University

National Institutes for Food and Drug Control

Beijing Hua Yuan Bo Chuang Technology Limited

Beijing Vitalstar Biotechnology Co., Ltd.

Beihao Stem Cell and Regenerative Medicine Translational Research Institute

Yan Shi

Sheng Ding

Saiyong Zhu

Caroline Desponts

Tongxiang Lin

Wenlin Li

Hongyan Zhou

Yang Zhang

Qian Jin

Shan Yu

Hongkui Deng

Fan Yang

Yang Liu

Ying Liu

Jun Xu

Na Zhang

Jia Zou

Wei Jiang

Jinlin Wang

Ming Yin

Yuanyuan Du

Lan He

Mingxiao Ding

Lingling Hou

Fuchou Tang

Nan Song

Jun Jia

Chengang Xiang

Xiu Lei Zhu

Zhonglin Lu

Xin Zhu

Xiangxiang Wu

Jing Xiong

The present invention relates to a cocrystal of progesterone, which is formed by the active ingredient progesterone and a cocrystal former which is selected from isophthalic acid, 4-formylbenzeneboronic acid and 3-nitrophthalic acid. The present invention also relates to the method for preparing the cocrystal of progesterone and use thereof for increasing the thickness of endometrium, improving progesterone's solubility or increasing progesterone's permeation rate.

Cocrystal of progesterone and preparation method and use thereof

A method for inducing reprogramming of a cell of a first type which is not a non-hepatocyte (non-hepatocyte cell), into a cell with functional hepatic drug metabolizing and transporting capabilities, is disclosed. The non-hepatocyte is induced to express or overexpress hepatic fate conversion and maturation factors, cultured in somatic cell culture medium, hepatocyte cell culture medium and hepatocyte maturation medium for a sufficient period of time to convert the non-hepatocyte cell into a cell with hepatocyte-like properties. The iHeps induced according to the methods disclosed herein are functional induced hepatocytes (iHeps) in that they express I and II drug-metabolizing enzymes and phase III drug transporters and show superior drug metabolizing activity compared to iHeps obtained by prior art methods. The iHeps thus provide a cell resource for pharmaceutical applications.

Methods for reprograming non-hepatocyte cells into hepatocyte cells

Use of a TNFR1-FADD-caspase8-caspase3 pathway inhibitor in preparation of a medicament for treating an immune system related disease caused by autoinducer, a method for screening a medicament for treating an immune system related disease caused by autoinducer and a method for treating an immune system related disease.

Use of autoinducer-related pathway in inducing apoptosis and anti-infective therapy

Embodiments of the present invention provide methods, program products, and systems to increase efficiency in message oriented middleware. Embodiments of the present invention can, responsive to receiving from an application an open request for a queue alias of a queue manager, provide to the application target cache information which includes a target name and a change flag count associated with the queue alias. Embodiments of the present invention can, responsive to receiving a message from the application that includes respective target cache information including a target name and a change flag count, determine a target location, wherein if the change flag count of the received message matches a current change flag count of the queue alias, the determined target location is a target location associated with the received target name.

Dynamic queue alias

An approach for providing simulated remote services locally. A local virtual access module collects remote services for local virtual service access. Service information associated with the remote services is collected to create local service packages. A network tunnel is created on firewalls where the remote services are accessible by associated local service packages. Local environment variables are created to establish local virtual service access and the local virtual service access module simulates cloud service access outside a cloud environment.

Local consumption of remote services

The present invention provides for identification and use of small molecules to induce pluripotency in mammalian cells as well as other methods of inducing pluripotency.

Combined chemical and genetic approaches for generation of induced pluripotent stem cells

Chemical approaches for generation of induced pluripotent stem cells

The present invention provided a simple three-step approach based on the combinational induction with activin A, all-trans retinoic acid and, optionally, other maturation factors which are able to induce embryonic stem cells to differentiate into insulin-producing cells. A kit used to induce embryonic stem cells to differentiate into insulin-producing cells was also provided.

Method of inducing embryonic stem cells into pancreatic cells

Growing community of inventors

Beijing, China

Yan Shi