Dingfu Biotarget Co., Ltd.

Shihuida Pharmaceutical Group (Jilin) Co., Ltd.

Yan Luan

Ting Xu

Jianjian Peng

Shilong Fu

Xiaoxiao Wang

Meng Zhao

Hui Ma

Xiaolong Pan

Shuli Ma

Kai Fu

Shanshan Ning

Yeqiong Fei

Jian Ding

Xiaojuan Liu

Songbing Qin

Provided are proteinaceous heterodimers, pharmaceutical compositions, medicaments and/or kits comprising the proteinaceous heterodimers, methods for producing the proteinaceous heterodimers, and uses thereof.

Proteinaceous heterodimer and use thereof

Provided are compositions and methods for treating cancer comprising the use of a immunoconjugate in combination with a cytotoxic agent or cytotoxic therapy. The immunoconjugate in combination with a cytotoxic agent or cytotoxic therapy shows synergistic effects in cancer treatment.

Methods and compositions for cancer treatment

The present disclosure provides an antibody, or an antigen binding fragment or variant thereof, which binds to CD27 and exhibits at least one of the following properties: specifically binds to CD27 with a Kof 10M or less; activates and/or increases CD27 mediated NF-&#x3ba;B activity; stimulates CD4and/or CD8T cell proliferation; binds to human CD27 expressed on a cell surface; stimulates secretion of IFN-&#x3b3; by CD4and/or CD8T cells. The present disclosure also provides a method for preparing and using said antibody.

Anti-CD27 antibodies and use thereof

Provided is an immunoconjugate useful in inhibiting tumor growth, and a composition and/or protein mixture comprising the immunoconjugate. Also provided are methods for the production of the immunoconjugate, as well as pharmaceutical uses of the immunoconjugate in inhibiting tumor growth, including but not limited to treatment of cancers.

Immunoconjugates comprising signal regulatory protein alpha

The present disclosure provides proteinaceous complexes, pharmaceutical compositions, medicaments and/or kits comprising the proteinaceous complexes, methods for producing the proteinaceous complexes, and uses thereof.

IL-10 EGFR antibody fusion protein and uses thereof

Disclosed are a fully human monoclonal antibody specifically binding to a CD137 or an antigen binding portion thereof. On one hand, provided are a CDR/variable region sequence of the antibody and an encoding nucleic acid sequence thereof; on the other hand, provided is a method for treating diseases using the antibody or the antigen binding portion thereof. a fully human monoclonal antibody specifically binding to a CD137 or an antigen binding portion thereof. On one hand, provided are a CDR/variable region sequence of the antibody and an encoding nucleic acid sequence thereof; on the other hand, provided is a method for treating diseases using the antibody or the antigen binding portion thereof.

Fully human antibody against human CD 137

The present application provides an anti-OX40 human antibody. In particular, a human antibody specifically binding to OX40 is obtained with yeast display screening, and the affinity of the antibody is improved with affinity maturation. The present application also provides a use of the antibody for the prevention or treatment of tumors.

Anti-OX40 antibody and application thereof

The present disclosure provides proteinaceous heterodimers, pharmaceutical compositions, medicaments and/or kits comprising the proteinaceous heterodimers, methods for producing the proteinaceous heterodimers, and uses thereof.

Growing community of inventors

Jiangsu, China

Yan Luan