Wisconsin Alumni Research Foundation

Smith + Nephew

Yan Lu

Mark D Markel

William Leo Murphy

Ben Kim Graf

Jae Sung Lee

Mathew Erle Mitchell

Kobi Iki

William M Ambrisco

Douglas M Lorang

Alan P Gannon

Richard Ranalli

Ryland B Edwards, Iii

Marie Meyer

Geoffrey Baer

The present disclosure generally relates to biodegradable and bioresorbable materials having a mineral layer on the surface of the material. More particularly, the disclosure relates to biodegradable and bioresorbable orthopedic devices having a degradable mineral layer on the surface thereof that can be used as a delivery vehicle for biological substances. Also provided are various methods of using the mineralized devices in tissue regeneration, including bone tissue engineering, and methods for producing the mineralized devices.

Biologically active sutures for regenerative medicine

A system for growing tissue based upon layers of an inorganic extracellular matrix, wherein each layer of the inorganic matrix is designed to dissolve at a separate rate and result in sequential growth factor delivery upon its dissolution.

Tissue regeneration system

An electrosurgical instrument includes a shaft, a flexible portion, and a head coupled to the shaft through the flexible portion and pivotably coupled to the flexible portion. The head includes a non-conductive surface and an electrically conductive surface. The flexible portion is configured to bias the non-conductive surface and the electrically conductive surface towards a tissue surface, such as cartilage. The non-conductive surface may include a material having a thermal conductivity less than or equal to about 30 W/m*K and/or a volume resistivity greater than or equal to about 1&#xd7;10ohm*cm. The non-conductive surface may include a ceramic such as Macor&#xae; ceramic, ZTA ceramic, and/or 99.5% alumina ceramic.

Cartilage treatment probe

Growing community of inventors

Fitchburg, WI, United States of America

Yan Lu