University of Tennessee Research Foundation

Gtx Corporation

The Ohio State University

Siemens Corporation

Oncternal Therapeutics, Inc.

Yan Lu

Duane Douglas Miller

James T Dalton

George Lo

Jianjun Chen

Chien-Ming Li

Zhao Wang

Sunjoo Ahn

Gerhard Zimmermann

Wei Li

Mohammad Abdullah Al Faruque

Charles B Duke

Siyuan Zhou

Li Wei

The present invention relates to colchicine-binding site compounds having anti-cancer activity, compositions comprising the same, and their use for treating various forms of cancer.

Compounds for treatment of cancer

The present invention relates to novel compounds having anti-cancer activity, methods of making these compounds, and their use for treating cancer and drug-resistant tumors, e.g. melanoma, metastatic melanoma, drug resistant melanoma, prostate cancer and drug resistant prostate cancer.

Compounds according to formula (I) are disclosed where Q is S, N, or O; X is optional, and can be O&#x2550;, S&#x2550;, &#x2550;N&#x2014;NH, &#x2550;N&#x2014;OH, or &#x2014;OH; Y is optional and can be &#x2014;N(H)&#x2014;, O, or Cto Chydrocarbon; and Rand Rare each independently substituted or unsubstituted single-, fused- or multiple-ring aryl or (hetero)cyclic ring systems. Methods of making these compounds, pharmaceutical compositions containing the compounds, and their use, particularly for treating or preventing cancer, are also disclosed.

Growing community of inventors

Bartlett, TN, United States of America

Yan Lu