Oncoimmune, Inc.

University of Michigan

Children's Research Institute, Children's National Medical Center

Oncolmmune, Inc.

Yan Liu

Yang Liu

Pan Zheng

Yin Wang

Sami N Malek

Christopher Bailey

Xing Chang

Lizhong Wang

Runhua Liu

Tao Zuo

Pan Zeng

A liposomal drug formulation for treating a disease in a patient characterized by overexpression of HIF-1&#x3b1; and/or HIF-2&#x3b1; includes a plurality of liposomes in a pharmaceutically acceptable carrier. The liposomes encapsulate echinomycin and are made from a peglyated phospholipid, a neutral phosphoglyceride, and a sterol. The PEGylated liposomes may be used to treat proliferative diseases, leukemia, cancer, autoimmune diseases and graft-versus-host disease.

Echinomycin formulation, method of making and method of use thereof

The present invention relates to treating a hematologic cancer using a Hypoxia-Inducible Factor (HIF inhibitor). The invention also relates to inducing acute myeloid leukemia remission using the HIF inhibitor. The invention further relates to inhibiting a maintenance or survival function of a cancer stem cell (CSC) using the HIF inhibitor.

Uses of hypoxia-inducible factor inhibitors

Provided herein are methods of treating a cancer in a subject comprising administering a FOXP3 protein, a nucleic acid encoding a FOXP3 protein, or an inducing compound which induces FOXP3 protein expression. Methods of altering a phenotype of a cancer cell or tumor cell, methods of inhibiting growth of such cells, and methods of inducing apoptosis of these cells are also provided herein. These methods comprise contacting the cell with a FOXP3 protein, a nucleic acid encoding a FOXP3 protein, or an inducing compound which induces FOXP3 protein expression. Further provided herein are diagnostic methods, comprising comparing the expression or structure of a FOXP3 protein or FOXP3 gene in a test sample to that of a normal or prior sample. A method of screening a test compound for anti-cancer activity comprising administering to cells the test compound and measuring FOXP3 protein or FOXP3 gene expression is moreover provided herein.

Materials and methods for FOXP3 tumor suppression

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Washington, DC, United States of America

Yan Liu