University of California

Yan Li

Zhongping Chen

Bruce J Tromberg

Yona Tadir

Yusi Miao

An in vivo optical biopsy applicator of the vaginal wall for treatment planning, monitoring, and imaging guided therapy is described herein. The applicator may include an imaging probe operatively coupled to a laser ablation device. The applicator allows for non-invasive optical tissue monitoring in order to define pre- and post menopausal parameters, pre- and post-treatment microscopic changes, and offers an objective scientific tool in order to compare currently available medical, non-medicated, and energy-based treatment protocols.

Optical biopsy applicators for treatment planning, monitoring, and image-guided therapy

An OCT system with a swept light source centered around 1.7 &#x3bc;m for identifying atherosclerotic plaque and visualization of large lipid pool is provided. Advantages for using the 1.7 &#x3bc;m swept source laser include higher contrast between lipid and normal tissue and deeper penetration of the optical signals from the 1.7 &#x3bc;m swept source laser into the tissue. With deeper penetration into the tissue, more structural information from deep within the tissue is obtained. The present invention also features multimodality imaging systems that integrate additional imaging systems into the OCT system at 1.7 &#x3bc;m. As an example, an integrated 1.3 &#x3bc;m and 1.7 &#x3bc;m OCT system is provided which simultaneously generates OCT images using both the OCT systems which are used to characterize and differentiate the types of tissue.

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Irvine, CA, United States of America

Yan Li